Document Detail

Increased hypoxic ventilatory sensitivity during exercise in man: are neural afferents necessary?
MedLine Citation:
PMID:  8071884     Owner:  NLM     Status:  MEDLINE    
1. The acute ventilatory response to 3 min periods of hypoxia (AHR) was examined in nine patients with clinically complete spinal cord transection (T4-T7) during (a) rest and (b) electrically induced leg exercise (EEL). 2. EEL was produced by surface electrode stimulation of the quadriceps muscles so as to cause the legs to extend at the knee against gravity. End-tidal PCO2 was held constant 1-2 mmHg above resting values throughout both protocols. 3. On exercise, the average increase in metabolic CO2 production (VCO2 +/- S.E.M.) was 41 +/- 5 ml min-1. Venous lactate levels did not rise with exercise. 4. Baseline euoxic ventilation did not increase significantly with EEL, but there was a consistent and highly significant increase in the ventilatory response to hypoxia during EEL (mean delta AHR +/- S.E.M. of 1.6 +/- 0.21 min-1). 5. We conclude that an increase in hypoxic sensitivity during exercise can occur in the absence of volitional control of exercise and in the absence of afferent neural input from the limbs.
J J Pandit; E Bergstrom; H L Frankel; P A Robbins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  477 ( Pt 1)     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM; S    
University Laboratory of Physiology, Oxford.
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MeSH Terms
Blood Pressure
Carbon Dioxide / physiology
Electric Stimulation
Exercise Test
Lactates / blood
Lactic Acid
Leg / innervation
Middle Aged
Neurons, Afferent / physiology*
Oxygen Consumption
Paraplegia / physiopathology
Physical Exertion / physiology*
Respiration / physiology*
Respiratory Function Tests
Spinal Cord Injuries
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid

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