| Increased hypoxic ventilatory response during 8 weeks at 3800 m altitude. | |
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MedLine Citation:
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PMID: 15450476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acclimatization to chronic hypoxia (CH) increases ventilation (V(I)) and the isocapnic hypoxic ventilatory response (HVR) over 2-14 days but hypoxic desensitization blunts the HVR after years of CH. We tested for hypoxic desensitization during the first 2 months of CH by studying five normal subjects at sea level (SL) and for 8 weeks at 3800 m (CH, PI(O(2)) approximately 90 Torr). We measured the isocapnic HVR (Delta V(I)/Delta Sa(O(2)) and tested for hypoxic ventilatory decline (HVD) by stepping Sa(O(2)) to 80% after 14 min at 90%. The HVR increased significantly after 2 days and remained significantly elevated for 8 weeks of CH. HVD was similar at SL and during 8 weeks of CH. Hence, hypoxic desensitization of the HVR does not occur after only 8 weeks of hypoxia and the increased HVR during this time does not involve changes in HVD. |
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Authors:
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Maarten D W Hupperets; Susan R Hopkins; Marieke G Pronk; Ivo J H Tiemessen; Nathalie Garcia; Peter D Wagner; Frank L Powell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 142 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2004-12-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology* Adult Altitude* Analysis of Variance Anoxia / physiopathology* Carbon Dioxide / blood Female Humans Hypercapnia / blood, physiopathology Male Oxygen / blood Pulmonary Ventilation / physiology* Respiration* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 17731/HL/NHLBI NIH HHS; M01 RR00827/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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