Document Detail

Increased hypoxic ventilatory response during 8 weeks at 3800 m altitude.
MedLine Citation:
PMID:  15450476     Owner:  NLM     Status:  MEDLINE    
Acclimatization to chronic hypoxia (CH) increases ventilation (V(I)) and the isocapnic hypoxic ventilatory response (HVR) over 2-14 days but hypoxic desensitization blunts the HVR after years of CH. We tested for hypoxic desensitization during the first 2 months of CH by studying five normal subjects at sea level (SL) and for 8 weeks at 3800 m (CH, PI(O(2)) approximately 90 Torr). We measured the isocapnic HVR (Delta V(I)/Delta Sa(O(2)) and tested for hypoxic ventilatory decline (HVD) by stepping Sa(O(2)) to 80% after 14 min at 90%. The HVR increased significantly after 2 days and remained significantly elevated for 8 weeks of CH. HVD was similar at SL and during 8 weeks of CH. Hence, hypoxic desensitization of the HVR does not occur after only 8 weeks of hypoxia and the increased HVR during this time does not involve changes in HVD.
Maarten D W Hupperets; Susan R Hopkins; Marieke G Pronk; Ivo J H Tiemessen; Nathalie Garcia; Peter D Wagner; Frank L Powell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  142     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-28     Completed Date:  2004-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA.
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MeSH Terms
Acclimatization / physiology*
Analysis of Variance
Anoxia / physiopathology*
Carbon Dioxide / blood
Hypercapnia / blood,  physiopathology
Oxygen / blood
Pulmonary Ventilation / physiology*
Time Factors
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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