| Increased human T lymphotropic virus type-1 (HTLV-1) proviral DNA in peripheral blood mononuclear cells and bronchoalveolar lavage cells from Japanese patients with HTLV-1-associated myelopathy. | |
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MedLine Citation:
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PMID: 8447519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human T lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in tropical areas and in southwestern Japan, and has now been identified among risk groups in the United States and some European countries. Patients with HAM/TSP may also have T lymphocyte alveolitis related to the HTLV-1 infection. To quantify proportions of HTLV-1-infected cells, a fragment of HTLV-1 proviral DNA was amplified from peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage (BAL) cells obtained from patients with HAM/TSP, non-HAM/TSP HTLV-1 carriers with chronic pulmonary inflammation, and asymptomatic HTLV-1 carriers. The proportion of HTLV-1-infected cells in PBMC from patients with HAM/TSP was much higher (3-30%) than that from asymptomatic HTLV-1 carriers (mostly < 1%), based on findings with the quantitative polymerase chain reaction. In non-HAM/TSP carriers with chronic pulmonary inflammation, HTLV-1-infected cells in PBMC were also increased, but not as markedly as that seen in patients with HAM/TSP. Integration of HTLV-1 was also noted in BAL cells from patients with HAM/TSP or non-HAM/TSP carriers with chronic pulmonary inflammation. However, in patients with HAM/TSP, there was a marked increase in HTLV-1-infected cells in the lung (7.5-30% of BAL cells), as compared with findings in non-HAM/TSP carriers (< 5%). These results suggest that increased HTLV-1 proviral DNA loading may play an important role in the development of T lymphocyte alveolitis and myelopathy in patients with HAM/TSP. |
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Authors:
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S Mita; M Sugimoto; M Nakamura; T Murakami; M Tokunaga; E Uyama; S Araki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 48 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-06 Completed Date: 1993-04-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 170-7 Citation Subset: AIM; IM; X |
Affiliation:
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First Department of Internal Medicine, Kumamoto University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Base Sequence Bronchoalveolar Lavage Fluid / cytology, microbiology* Carrier State / blood, microbiology, pathology Cell Count Chronic Disease DNA, Viral / analysis*, blood, chemistry Densitometry Female Genes, env Human T-lymphotropic virus 1 / genetics, isolation & purification* Humans Leukocytes, Mononuclear / microbiology Male Middle Aged Molecular Sequence Data Paraparesis, Tropical Spastic / blood, microbiology*, pathology Pneumonia / blood, microbiology, pathology Polymerase Chain Reaction Proviruses / genetics, isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
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