| Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. | |
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MedLine Citation:
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PMID: 20962157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recently, a genetic variant (rs738409; C→G) of the PNPLA3 gene was identified to be associated with increased hepatic fat deposition, and the effect was more pronounced in Hispanics. Animal models have also shown that PNPLA3 expression can be regulated by dietary carbohydrate. OBJECTIVE: The aim of this study was to examine whether the influence of PNPLA3 genotype on hepatic fat is modulated by dietary factors in Hispanic children. DESIGN: PNPLA3 was genotyped in 153 Hispanic children (75% female, ages 8-18 y) by using the TaqMan method. Dietary intake was assessed by using three 24-h dietary recalls or diet records. Visceral adipose tissue (VAT), subcutaneous abdominal adipose tissue (SAAT), and hepatic fat fraction (HFF) were assessed in multiple abdominal slices by magnetic resonance imaging. Analysis of covariance was used to assess the diet × genotype interaction in liver fat, with the following a priori covariates: sex, age, energy, VAT, and SAAT. RESULTS: HFF was influenced by a significant interaction between genotype and diet (genotype × carbohydrate, P = 0.04; genotype × total sugar, P = 0.01). HFF was positively related to carbohydrate (r = 0.31, P = 0.04) and total sugar (r = 0.34, P = 0.02) intakes but only in the GG group, independent of covariates. Dietary variables were not related to HFF in the CC or CG group or to other fat depots in all genotype groups. CONCLUSIONS: These findings suggest that Hispanic children carrying the GG genotype are susceptible to increased hepatic fat when dietary carbohydrate intake, specifically sugar, is high. Specific dietary interventions based on genetic predisposition in this population may lead to more effective therapeutic outcomes for fatty liver. This trial was registered at clinicaltrials.gov as NCT00697580, 195-1642394A1, and NCT00693511. |
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Authors:
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Jaimie N Davis; Kim-Anne Lê; Ryan W Walker; Susanna Vikman; Donna Spruijt-Metz; Marc J Weigensberg; Hooman Allayee; Michael I Goran |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1522-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. jaimieda@usc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00693511; NCT00697580 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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ethnology,
genetics Adolescent Child Diet Records Dietary Carbohydrates / administration & dosage Dietary Sucrose / administration & dosage* Fatty Liver / ethnology, genetics* Female Food Habits Genotype Hispanic Americans / genetics* Humans Lipase / genetics* Liver / metabolism* Male Membrane Proteins / genetics* Overweight / ethnology, genetics* Polymorphism, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
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1K01DK078858-01/DK/NIDDK NIH HHS; K01 DK078858-01/DK/NIDDK NIH HHS; P60 MD002254/MD/NIMHD NIH HHS; R01 HD/HL 33064/HD/NICHD NIH HHS; R01HL079353/HL/NHLBI NIH HHS; U54 CA 116848/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Sucrose; 0/Membrane Proteins; EC 3.1.1.3/Lipase; EC 3.1.1.3/adiponutrin, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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