Document Detail


Increased hemostasis potential persists in women with previous thromboembolism with or without APC resistance.
MedLine Citation:
PMID:  14675088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Activated thrombin generation and depressed fibrinolysis due to the presence of activated protein C (APC) resistance with or without factor (F)V Leiden mutation are associated with development of deep venous thrombosis (DVT). OBJECTIVE: A better understanding of the mechanism behind the risk of recurrence of DVT, using our new, recently developed assay of overall hemostasis potential (OHP). PATIENTS AND METHODS: Levels of OHP, as well as APC resistance and FV Leiden mutation, were determined in 88 women (cases) who had previously experienced DVT in connection with pregnancy, and in 25 young healthy individuals (controls). Clotting time and clot lysis time were also investigated. RESULTS: OHP levels in the patients were increased compared with the controls. In the cases with APC resistance and the Leiden mutation this imbalance in hemostasis potential was more severe than in those without. The group with the more severe imbalance had shorter clotting times and longer clot lysis times. CONCLUSIONS: A procoagulant state perseveres in patients with a history of pregnancy-related DVT, even after the symptomatic phase is over. The mechanisms behind such an imbalance in overall hemostasis are enhanced thrombin generation and depressed fibrinolysis. These findings may underscore the need for thromboprophylaxis to prevent recurrence of thromboembolism in risk situations.
Authors:
A Antovic; M Blombäck; K Bremme; M Van Rooijen; S He
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  1     ISSN:  1538-7933     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  2531-5     Citation Subset:  IM    
Affiliation:
Coagulation Research/Department of Surgical Sciences, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden. aleksandra@antovic@ks.se
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / physiopathology*
Adolescent
Adult
Blood Coagulation Tests
Case-Control Studies
Factor V / physiology
Female
Fibrinolysis
Hemostasis / physiology*
Humans
Middle Aged
Pregnancy
Pregnancy Complications, Cardiovascular / physiopathology
Recurrence
Thrombin / biosynthesis
Thromboembolism / physiopathology*
Thrombophilia / diagnosis,  etiology
Venous Thrombosis / physiopathology
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; EC 3.4.21.5/Thrombin

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