| Increased growth inhibition and DNA lesions in human colon adenocarcinoma cells treated with methotrexate or 5-fluorodeoxyuridine followed by calmodulin inhibitors. | |
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MedLine Citation:
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PMID: 2453268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antineoplastic agents methotrexate and 5-fluorodeoxyuridine induce DNA lesions, although the drugs are not incorporated into DNA. The lesions arise as a result of reduced repair of damage occurring in DNA independently of the treatment with antineoplastic agents. When cells containing DNA lesions are treated with calmodulin inhibitors (W-7, phenothiazine, promethazine), the amount of lesions is increased, in all probability due to reduced DNA repair. This is paralleled by increased growth inhibition. Hence by inhibiting calmodulin, one can modulate the levels of DNA lesions and change the growth-inhibitory effect induced by methotrexate or 5-fluorodeoxyuridine. This strongly supports the importance of this type of DNA lesion in the toxic effects induced by the drugs. |
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Authors:
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U Lönn; S Lönn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer research Volume: 48 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-29 Completed Date: 1988-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3319-23 Citation Subset: IM |
Affiliation:
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Radiumhemmet, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology Bleomycin / pharmacology Calmodulin / antagonists & inhibitors* Cell Survival / drug effects Colonic Neoplasms / pathology DNA Damage* Floxuridine / pharmacology* Humans Methotrexate / pharmacology* Phenothiazines / pharmacology Promethazine / pharmacology Sulfonamides / pharmacology Tumor Cells, Cultured / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Phenothiazines; 0/Sulfonamides; 11056-06-7/Bleomycin; 50-91-9/Floxuridine; 59-05-2/Methotrexate; 60-87-7/Promethazine; 65595-90-6/W 7; 92-84-2/phenothiazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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