Document Detail


Increased glycolysis as protective adaptation of energy depleted, degenerating human hibernating myocardium.
MedLine Citation:
PMID:  12619871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the current study on human hibernating myocardium (HHM), we tested the hypothesis that increased glycolysis might exert a positive effect during a supply-demand balance situation by augmentation of myocardial energy formation. In 14 patients HHM was preoperatively detected by clinical methods and validated by the recovery of contractile function three months following revascularization. During open-heart surgery, transmural biopsies were removed from the hibernating areas and analyzed using biochemical and morphologic methods. Metabolite contents were normalized for the degree of fibrosis (control: 9.8 +/- 0.5%, HHM 28.1 +/- 3.0%; p < 0.05), providing values for cardiomyocytes only. In energy depleted HHM, severe intracellular degeneration, glycogen accumulation and myocyte loss were found. Elevated lactate levels (2.22 +/- 0.26 vs. 25.38 +/- 3.53 micromol/wet wt, p < 0.001) were indicative of an increased anaerobic glycolytic flux. In conclusion the presence of abundant intracellular glycogen and an increased anaerobic glycolysis in HHM is indicative of a protective adaptation of this myocardium, which might balance energy deficit and may limit structural damage.
Authors:
Achim M Vogt; Albrecht Elsässer; Holger Nef; Christoph Bode; Wolfgang Kübler; Jutta Schaper
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  242     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-06     Completed Date:  2003-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University of Freiburg/Br., Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Apoptosis
Cytoprotection
Energy Metabolism
Glycolysis*
Heart / physiology*
Heart Catheterization
Humans
In Situ Nick-End Labeling
Ischemia / metabolism
Myocardial Stunning / pathology,  physiopathology*
Myocardium / metabolism*,  pathology*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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