| Increased glycated hemoglobin level in non-diabetic nephrotic children is associated with oxidative stress. | |
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MedLine Citation:
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PMID: 18175659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of nephrotic syndrome. Possible interrelations of glycated hemoglobin with reduced glutathione and malondialdehyde were evaluated in nephrotic syndrome patients. Eighteen nephrotic syndrome patients and 15 healthy controls were enrolled for this study. Glycated hemoglobin, reduced glutathione, malondialdehyde and fasting glucose were analyzed for their correlation in both the groups. In nephrotic syndrome patients, while glycated hemoglobin and malondialdehyde levels were found to be significantly increased, glutathione levels decreased significantly when compared with controls. Glycated hemoglobin was found to have a significant positive correlation with malondialdehyde and a negative correlation with glutathione. Erythrocytes depleted of glutathione, by pre-treatment with 1-chloro-2, 4-dinitrobenezene, were found to have higher glycated hemoglobin levels when compared with erythrocytes incubated with glucose alone. These data suggest that glycated hemoglobin levels are closely associated with malondialdehyde and glutathione in nephrotic syndrome patients. |
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Authors:
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R Balamurugan; N Selvaraj; Z Bobby; V Sathiyapriya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 51 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2007 Apr-Jun |
Date Detail:
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Created Date: 2008-01-07 Completed Date: 2008-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 153-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Female Glutathione / analysis Hemoglobin A, Glycosylated / analysis* Humans Linear Models Male Malondialdehyde / analysis Nephrotic Syndrome / blood, metabolism* Oxidative Stress* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 542-78-9/Malondialdehyde; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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