Document Detail

Increased glutamate release into the intercellular space of the nucleus accumbens (N. accumbens) during substitution of food reinforcement with aversive or neutral stimuli.
MedLine Citation:
PMID:  15115317     Owner:  NLM     Status:  MEDLINE    
Experiments on Sprague-Dawley rats using vital intracerebral dialysis and HPLC with electrochemical detection demonstrated that presentation of the animals with inedible imitation food or food containing a bitter flavor instead of the expected food reinforcement led to rapid increases in glutamate levels in the intercellular space of the nucleus accumbens. There was no change in the glutamate level during presentation of the same stimuli to rats not expecting to receive food reinforcement. These data suggest that non-correspondence between the expected and actual values of reinforcement may be an important factor determining the extracellular glutamate level in the nucleus accumbens during food-related behavior.
N B Saul'skaya; M O Mikhailova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  34     ISSN:  0097-0549     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-29     Completed Date:  2004-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM    
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
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MeSH Terms
Avoidance Learning / physiology*
Extracellular Space / metabolism*
Feeding Behavior / physiology
Glutamic Acid / secretion*
Microdialysis / instrumentation
Nucleus Accumbens / metabolism*
Rats, Sprague-Dawley
Reinforcement (Psychology)*
Reg. No./Substance:
56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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