| Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: a magnetic resonance spectroscopy study. | |
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MedLine Citation:
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PMID: 20191578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Fibromyalgia (FM) has been defined as a systemic disorder that is clinically characterized by pain, cognitive deficit, and the presence of associated psychopathology, all of which are suggestive of a primary brain dysfunction. This study was undertaken to identify the nature of this cerebral dysfunction by assessing the brain metabolite patterns in patients with FM through magnetic resonance spectroscopy (MRS) techniques. METHODS: A cohort of 28 female patients with FM and a control group of 24 healthy women of the same age were studied. MRS techniques were used to study brain metabolites in the amygdala, thalami, and prefrontal cortex of these women. RESULTS: In comparison with healthy controls, patients with FM showed higher levels of glutamate/glutamine (Glx) compounds (mean +/- SD 11.9 +/- 1.6 arbitrary units [AU] versus 13.4 +/- 1.7 AU in controls and patients, respectively; t = 2.517, 35 df, corrected P = 0.03) and a higher Glx:creatine ratio (mean +/- SD 2.1 +/- 0.4 versus 2.4 +/- 1.4, respectively; t = 2.373, 35 df, corrected P = 0.04) in the right amygdala. In FM patients with increased levels of pain intensity, greater fatigue, and more symptoms of depression, inositol levels in the right amygdala and right thalamus were significantly higher. CONCLUSION: The distinctive metabolic features found in the right amygdala of patients with FM suggest the possible existence of a neural dysfunction in emotional processing. The results appear to extend previous findings regarding the dysfunction in pain processing observed in patients with FM. |
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Authors:
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Manuel Vald?s; Antonio Collado; Nuria Bargall?; Mireia V?zquez; Lorena Rami; Emili G?mez; Manel Salamero |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 62 ISSN: 1529-0131 ISO Abbreviation: Arthritis Rheum. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 1829-36 Citation Subset: AIM; IM |
Affiliation:
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Institut d'Investigacions Biom?diques August Pi i Sunyer and Hospital Cl?nic of Barcelona, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anxiety
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complications,
diagnosis Brain / metabolism* Brain Mapping Chi-Square Distribution Creatine / metabolism Depression / complications, diagnosis Female Fibromyalgia / complications, metabolism* Glutamic Acid / metabolism* Glutamine / metabolism* Humans Magnetic Resonance Spectroscopy Psychiatric Status Rating Scales |
| Chemical | |
Reg. No./Substance:
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56-85-9/Glutamine; 56-86-0/Glutamic Acid; 57-00-1/Creatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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