Document Detail


Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration.
MedLine Citation:
PMID:  20981508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animals chronically exposed to stressors with access to diets high in fat and sugar consume and prefer these diets, a result consistent with the association between stress and comfort food ingestion in humans. As social subordination in rhesus monkeys provides an ethologically relevant translational model of psychosocial stress, we tested the hypothesis that differences in food intake between dominant and subordinate female monkeys are due to corticotropin-releasing hormone-(CRH) induced alteration in sensitivity to ghrelin, a potent orexigenic signal. We assessed food intake of animals given a choice between a low (LCD) and high calorie diet (HCD) in response to 4-day treatment with the CRH receptor antagonist, astressin B, and to an acute treatment of ghrelin. Ghrelin stimulated intake of LCD in subordinates but did not further increase consumption of HCD, whereas ghrelin decreased LCD consumption without affecting HCD intake in dominant females. Astressin B decreased cortisol levels and increased preference for and intake of the HCD in subordinates and decreased calorie intake and HCD preference in dominant animals. These results suggest that increased caloric intake by subordinates may, in part, be explained by a greater sensitivity to postprandial increases in ghrelin and that CRH receptor antagonism leading to a decrease in cortisol has mixed effects on food choice depending on an individual's stress background.
Authors:
Vasiliki Michopoulos; Tammy Loucks; Sarah L Berga; Jean Rivier; Mark E Wilson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-17
Journal Detail:
Title:  Endocrine     Volume:  38     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2011-03-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-34     Citation Subset:  IM    
Affiliation:
Division of Psychobiology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA. vmichop@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Aggression / drug effects
Animals
Behavior, Animal / drug effects,  physiology
Corticotropin-Releasing Hormone / pharmacology*
Energy Intake / drug effects*,  physiology*
Feeding Behavior / drug effects,  physiology
Female
Food Preferences / drug effects,  physiology
Ghrelin / blood*
Hydrocortisone / blood
Macaca mulatta
Ovariectomy
Peptide Fragments / pharmacology*
Receptors, Corticotropin-Releasing Hormone / metabolism
Social Behavior
Social Dominance
Stress, Psychological / metabolism*
Grant Support
ID/Acronym/Agency:
DK026741/DK/NIDDK NIH HHS; F31 MH085445-01A1/MH/NIMH NIH HHS; F31 MH085445-02/MH/NIMH NIH HHS; HD46501/HD/NICHD NIH HHS; P01 DK026741-20/DK/NIDDK NIH HHS; R01 HD046501-04/HD/NICHD NIH HHS; RR00165/RR/NCRR NIH HHS; T32-MH073525/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Peptide Fragments; 0/Receptors, Corticotropin-Releasing Hormone; 0/astressin B; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections
Erratum In:
Endocrine. 2010 Dec;38(3):417

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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