| Increased gastric-end tidal P(CO2) gap during exercise at high altitude measured by gastric tonometry. | |
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MedLine Citation:
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PMID: 17394417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using automated air gastric tonometry, the hypothesis that gastric perfusion is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P(CO2) gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P(CO2) gradient at the lower work rate (0.22 vs. 0.18, p 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P(CO2) gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions. |
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Authors:
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Daniel Martin; Stuart McCorkell; Andre Vercueil; Paul Gunning; Mark Cox; John Dick; Monty Mythen; Mike Grocott |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: High altitude medicine & biology Volume: 8 ISSN: 1527-0297 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-30 Completed Date: 2007-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 50-5 Citation Subset: IM; S |
Affiliation:
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Centre for Altitude Space and Extreme Environment Medicine, UCL Institute for Human Health and Performance, Archway Campus, Highgate Hill, London, United Kingdom. dan.s.martin@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / metabolism* Exercise / physiology* Gastric Mucosa / blood supply*, metabolism*, secretion Humans Male Manometry / methods* Monitoring, Physiologic / methods Oxygen Consumption Reference Values Regression Analysis Tidal Volume |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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