Document Detail


Increased frequency of restless legs syndrome in atopic dermatitis.
MedLine Citation:
PMID:  22712855     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background.  Restless legs syndrome (RLS) is characterized by an unpleasant sensation in the legs, which is difficult to describe, but produces an urge to move the legs frequently. Aim.  To assess the prevalence and severity of RLS in patients with atopic dermatitis (AD) and patients with psoriasis, and to investigate the factors potentially associated with RLS. Methods.  In total, 253 people were enrolled (120 with AD, 50 with psoriasis and 83 healthy controls). A diagnosis of RLS was made according to the criteria of the International RLS Study Group (IRLSSG), and severity was assessed using the IRLSSG severity scale. Results.  RLS was significantly more common in patients with AD (40.8%) than in patients with psoriasis (18.0%) or in controls (10.8%) (P < 0.01 and P < 0.001, respectively). Prevalence of RLS was higher in patients with active AD than in those with inactive AD (55.3% vs. 23.6%) or controls. There was a significant difference in RLS prevalence between patients with active and those with iactive AD, between patients with active AD and healthy controls, between patients with active AD and patients with psoriasis, and between patients with inactive AD and healthy controls (P < 0.001, P < 0.001, P < 0.001, P = 0.04, respectively). There was no significant difference in RLS prevalence between patients with active AD and patients with psoriasis, or between patients with psoriasis and healthy controls (P > 0.05). Of patients who were positive for RLS, 56.9% had a family history of atopy and 40.3% had a family history of RLS, and there was a significant relationship between the presence of RLS and family history of atopy or RLS (P < 0.001 for both). Conclusions.  RLS is common in patients with AD, particularly in those with active disease.
Authors:
D Cicek; N Halisdemir; S B Dertioglu; M S Berilgen; S Ozel; C Colak
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  37     ISSN:  1365-2230     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  469-476     Citation Subset:  -    
Copyright Information:
© The Author(s). CED © 2012 British Association of Dermatologists.
Affiliation:
Departments of Dermatology, Faculty of Medicine, Firat University Elazig, Turkey Department of Statistics, Faculty of Arts and Sciences, Firat University, Elazig, Turkey Departments of Dermatology, Faculty of Medicine, Harran University Sanliurfa, Turkey Departments of Neurology, Faculty of Medicine, Firat University Elazig, Turkey Departments of Neurology, Besni State Hospital, Adiyaman, Turkey Department of Statistics, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey.
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