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Increased frequencies of CD4(+)CD25(+)FOXP3(+) regulatory T cells in human nasal inverted papilloma.
MedLine Citation:
PMID:  21136544     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study was to investigate the presence of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells both in peripheral blood and local tumors in patients with nasal inverted papilloma (NIP). METHODS: By using flow cytometry, the frequencies of CD4(+)CD25(+)FOXP3(+) Treg cells in both peripheral blood and tissues from 18 patients with NIP and 8 control subjects were determined. CCL22 and CCL17 proteins in NIP tumors were analyzed by using enzyme-linked immunosorbent assay. The suppressive capacity of Treg cells was estimated by WST-8 and enzyme-linked immunosorbent assay (ELISA; interferon-gamma [IFN-γ] and interleukin-4 [IL-4]) analysis. RESULTS: Patients with NIP showed increased CD4(+)CD25(+)FOXP3(+) Treg cell frequencies in tumor tissues and CD4(+) T cell fraction rather than in peripheral blood. CCL22 increased in NIP tumors. Phytohemagglutinin (PHA)-induced proliferation and cytokine production of CD4(+)CD25(-) T cells were suppressed equally well by CD4(+)CD25(high) cells from both patients with NIP and controls. CONCLUSION: Our study demonstrated the increased frequencies of CD4(+)CD25(+)FOXP3(+) Treg cells in NIP tumors, which might be influenced by CCL22. © 2010 Wiley Periodicals, Inc. Head Neck, 2010.
Authors:
Yili Gu; Chengshuo Wang; Demin Han; Luo Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-6
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Key Laboratory of Otolaryngology-Head and Neck Surgery (Capital Medical University, Ministry of Education of China), Beijing Institute of Otorhinolaryngology, Beijing 100005, China.
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