| Increased fetal plasma prostaglandin E2 concentrations during fetal placental embolization in pregnant sheep. | |
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MedLine Citation:
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PMID: 7631709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to examine the effect of chronic fetal placental embolization on fetal plasma prostaglandin E2 concentrations. STUDY DESIGN: Fourteen pregnant sheep were studied (seven embolized and seven controls) for 10 days between 0.84 and 0.91 of gestation. Daily injections of nonradioactive microspheres were made to decrease fetal arterial oxygen content by 30% to 35% of preembolization values. RESULTS: In response to repeated embolization, fetal plasma prostaglandin E2 concentrations increased significantly on day 1, declined to near control levels on days 2 to 6, but were significantly elevated again after day 7. Maternal prostaglandin E2 levels remained unchanged throughout the study. Fetal plasma prostaglandin E2 levels increased significantly with decreasing fetal oxygenation when fetal arterial oxygen content was < 2.0 mmol/L. CONCLUSION: We conclude that there is increased production of prostaglandin E2 by the placenta during progressive fetal hypoxemia induced by fetal placental embolization. We speculate that the progressive increase in prostaglandin E2 may be an important hormonal adaptive mechanism to maintain fetal homeostasis during the development of placental insufficiency. |
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Authors:
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J Murotsuki; J R Challis; L Johnston; R Gagnon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 173 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-09-06 Completed Date: 1995-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynaecology, St. Joseph's Health Centre, Lawson Research Institute, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dinoprostone / blood Embolism / blood Female Fetal Blood / chemistry* Fetal Hypoxia / blood* Oxygen / blood Placenta / blood supply* Pregnancy Radioimmunoassay Sheep |
| Chemical | |
Reg. No./Substance:
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363-24-6/Dinoprostone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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