Document Detail

Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition of norepinephrine uptake in pregnant sheep.
MedLine Citation:
PMID:  17381469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. STUDY DESIGN: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of i.v. NE. RESULTS: NET inhibition increased both fetal and maternal mean arterial blood pressure (p < 0.001, respectively). CONCLUSION: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure.
S R Hansson; B Bottalico; I Amer-Wahlin; K Marsál; D Ley
Related Documents :
8191329 - Do high fetal catecholamine levels affect heart rate variability and meconium passage d...
19391249 - Nitric oxide reduces vagal baroreflex sensitivity in the late gestation fetus.
24592799 - Efficacy of isometric exercise full knee extension horizontally (fkeh)--a new and simpl...
1561559 - The effect of continuous low-dose epidural analgesia on uterine work during the active ...
7198589 - Physical and chemical properties of fetal membranes: their relation to parity, maternal...
23629829 - Sectioning the medial patellofemoral ligament alters patellofemoral joint kinematics an...
22165459 - Comparison of ropivacaine and lidocaine with epinephrine for infiltration anesthesia in...
16671339 - Collagen metabolism in extracellular matrix may be involved in arterial stiffness in ol...
3034739 - Ace-inhibitors in the treatment of elderly hypertensives.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Obstetrics and Gynecology, Lund University, Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic Uptake Inhibitors / pharmacology
Blood Pressure / drug effects*
Fetus / physiology*
Morpholines / pharmacology
Norepinephrine / metabolism*,  pharmacology*
Norepinephrine Plasma Membrane Transport Proteins / drug effects*
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Morpholines; 0/Norepinephrine Plasma Membrane Transport Proteins; 51-41-2/Norepinephrine; 98769-81-4/reboxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bronchiolitis due to respiratory syncytial virus in hospitalized children: a study of seasonal rhyth...
Next Document:  Liver disease as risk factor for cystic fibrosis-related diabetes development.