Document Detail

Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition of norepinephrine uptake in pregnant sheep.
MedLine Citation:
PMID:  17381469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. STUDY DESIGN: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of i.v. NE. RESULTS: NET inhibition increased both fetal and maternal mean arterial blood pressure (p < 0.001, respectively). CONCLUSION: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure.
S R Hansson; B Bottalico; I Amer-Wahlin; K Marsál; D Ley
Related Documents :
2183109 - The effects of epidural anesthesia on the doppler velocimetry of umbilical and uterine ...
11003309 - Effect of different doses of prostaglandin e2 on intrauterine pressure and uterine moti...
16726109 - The use of catheter-tipped pressure transducers for chronic measurement of genital trac...
7198589 - Physical and chemical properties of fetal membranes: their relation to parity, maternal...
11120389 - Dose-related differences in the distribution of cocaine in the maternal-fetoplacental c...
12050259 - Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro.
16505639 - Pedobarographic findings in patients with knee osteoarthritis.
20409859 - A specific training on hypertension guidelines improves blood pressure control by more ...
8854749 - Autonomic interactions and chronotropic control of the heart: heart period versus heart...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Obstetrics and Gynecology, Lund University, Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic Uptake Inhibitors / pharmacology
Blood Pressure / drug effects*
Fetus / physiology*
Morpholines / pharmacology
Norepinephrine / metabolism*,  pharmacology*
Norepinephrine Plasma Membrane Transport Proteins / drug effects*
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Morpholines; 0/Norepinephrine Plasma Membrane Transport Proteins; 51-41-2/Norepinephrine; 98769-81-4/reboxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bronchiolitis due to respiratory syncytial virus in hospitalized children: a study of seasonal rhyth...
Next Document:  Liver disease as risk factor for cystic fibrosis-related diabetes development.