| Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications. | |
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MedLine Citation:
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PMID: 22854307 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper provides a review of the effects of relaxin-3 and structurally related analogues on food intake and related behaviours, in relation to hypothalamic neural networks and chemical messengers known to control feeding, metabolism and body weight, including other neuropeptides and hormones. Soon after relaxin-3 was discovered, pharmacological studies identified the ability of the native peptide to stimulate feeding acutely in adult rats. Although interpretation of these data was confounded by ligand cross-reactivity at relaxin-family peptide (RXFP) receptors, studies with relaxin-3 analogues selective for the native relaxin-3 receptor, RXFP3, confirmed that acute and chronic activation of RXFP3 increased feeding and weight gain, and produced changes in plasma leptin and insulin. These studies also identified the hypothalamus as a locus of action. Studies are now required to identify RXFP3-positive neuron populations involved in the effects of relaxin-3/RXFP3 signalling on metabolic and neuroendocrine homeostasis, and to determine whether peptide-based, nonpeptide-based or gene-based RXFP3 treatments can alter food intake and body weight in animal models of obesity and eating disorders, as a reflection of the therapeutic potential of this newly identified transmitter system. |
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Authors:
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Despina E Ganella; Philip J Ryan; Ross A D Bathgate; Andrew L Gundlach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Behavioural pharmacology Volume: 23 ISSN: 1473-5849 ISO Abbreviation: Behav Pharmacol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013016 Medline TA: Behav Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 516-25 Citation Subset: IM |
Affiliation:
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aFlorey Neuroscience Institutes bDepartment of Biochemistry and Molecular Biology cDepartment of Anatomy and Neuroscience dFlorey Department of Neuroscience, The University of Melbourne, Victoria, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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