| Increased expression of telomere-related proteins correlates with resistance to radiation in human laryngeal cancer cell lines. | |
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MedLine Citation:
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PMID: 19424630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes of telomere-associated gene expressions and bionomical characteristics that occur in two human larynx squamous carcinoma cell lines (Hep-2 and Hep-2R), with different radiosensitivities in vitro were explored in the present study. Based on previous research, elevated POT1 and TPP1 expressions were detected by reverse transcription-PCR and Western blotting in Hep-2R cell lines. Furthermore, Hep-2R cells showed increased recovery ratio accompanied by a reduction of cell arrested in G2/S phase, suggesting that the radioresistance of Hep-2R cells was due to a faster growth in which telomere length had recently been demonstrated to be a powerful prognostic marker. These results manifest that radioresistant Hep-2R cell lines showed certain changes in gene expression and bionomical profiles that are different from the profile changes of the more-sensitive Hep-2 cell lines, and that evaluation of telomere-associated genes may be a prognostic marker for response to radiotherapy in larynx squamous cell carcinoma (LSCC). |
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Authors:
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Tian Tang; Fu-Xiang Zhou; Han Lei; Hai-Jun Yu; Cong-Hua Xie; Yun-Feng Zhou; Shi-Quan Liu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 21 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-08 Completed Date: 2009-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1505-9 Citation Subset: IM |
Affiliation:
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Department of Radio-Chemotherapy, Zhongnan Hospital, Wuhan University, Wuhan 430071, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Carcinoma, Squamous Cell / genetics, metabolism*, pathology Cell Cycle / radiation effects Cell Line, Tumor Cell Proliferation / radiation effects Cell Survival / radiation effects Dose-Response Relationship, Radiation Gene Expression Regulation, Neoplastic / radiation effects Humans Laryngeal Neoplasms / genetics, metabolism*, pathology Radiation Tolerance* Reverse Transcriptase Polymerase Chain Reaction Telomere-Binding Proteins / genetics, metabolism, radiation effects* Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/ACD protein, human; 0/POT1 protein, human; 0/Telomere-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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