Document Detail

Increased expression of p75NTR by neural crest-derived cells in vivo during mitosis.
MedLine Citation:
PMID:  10757508     Owner:  NLM     Status:  MEDLINE    
The responses to neurotrophic factors may be modulated by changes in the levels of expression of their receptors. The aim of this study was to determine whether neural precursors in vivo show cell cycle phase-dependent changes in expression of p75NTR and Ret. Preparations of embryonic mouse gut were processed for Ret or p75NTR immunohistochemistry to identify neural crest-derived cells, and cells undergoing mitosis were identified using a fluorescent nucleic acid stain. Neural crest-derived cells undergoing mitosis showed over twice the levels of p75NTR immunoreactivity (pixel intensity measured on a confocal microscope) on their surface to that shown by nonmitotic neural crest cells. However, there was no significant difference between the levels of Ret on mitotic and nonmitotic neural crest cells.
H M Young
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  11     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-05     Completed Date:  2000-06-05     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  725-8     Citation Subset:  IM    
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, VIC, Australia.
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MeSH Terms
Carrier Proteins / analysis*,  biosynthesis*
Drosophila Proteins*
Embryo, Mammalian
Enteric Nervous System / cytology,  embryology,  metabolism
Fluorescent Antibody Technique
Intracellular Signaling Peptides and Proteins*
Mice, Inbred BALB C
Mitosis / physiology*
Neural Crest / cytology,  embryology*,  metabolism*
Proto-Oncogene Proteins / analysis,  biosynthesis
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases / analysis,  biosynthesis
Receptors, Nerve Growth Factor / analysis,  biosynthesis*
Reg. No./Substance:
0/Carrier Proteins; 0/Drosophila Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Nerve Growth Factor; 0/Zfp110 protein, mouse; EC Proteins c-ret; EC Protein-Tyrosine Kinases; EC oncogene protein, Drosophila; EC protein, mouse

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