| Increased expression of p130 in Alzheimer disease. | |
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MedLine Citation:
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PMID: 17006760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive. In this study, we focused on the retinoblastoma-related protein p130 in AD. p130 is a transcriptional regulator that complexes with E2F4/5 in the nucleus and suppresses genes that regulate entry into the cell cycle. Interestingly, our results show that there are increases in p130 in cytoplasm of susceptible pyramidal neurons as well as neuroglia, often surrounding senile plaques, and within Hirano bodies in AD. By marked contrast, p130 is found at background levels in non-diseased, age-matched controls. Our data suggest that, despite its upregulation, the aberrant localization of p130 to the neuronal cytoplasm facilitates neuronal cell cycle re-entry in AD. |
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Authors:
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Laura A Previll; Meredith E Crosby; Rudy J Castellani; Robert Bowser; George Perry; Mark A Smith; Xiongwei Zhu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-09-28 |
Journal Detail:
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Title: Neurochemical research Volume: 32 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2007 Apr-May |
Date Detail:
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Created Date: 2007-03-23 Completed Date: 2007-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 639-44 Citation Subset: IM |
Affiliation:
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Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / genetics*, metabolism*, pathology Amyloid beta-Protein / metabolism Astrocytes / metabolism Brain Chemistry Cytoplasm / metabolism Female Gene Expression Regulation / physiology Hippocampus / chemistry, pathology Humans Immunohistochemistry Male Middle Aged Neocortex / chemistry, pathology Neurofibrillary Tangles / metabolism, pathology Neuroglia / metabolism Pyramidal Cells / metabolism Retinoblastoma-Like Protein p130 / biosynthesis*, genetics Senile Plaques / metabolism Up-Regulation / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Retinoblastoma-Like Protein p130 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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