Document Detail

Increased expression of matrix metalloproteinase-9 and hepatocyte growth factor in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus.
MedLine Citation:
PMID:  20457496     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In approximately 60% of infants with posthemorrhagic hydrocephalus (PHH), ventricular dilation resolves by unknown intrinsic mechanisms, without the need for a shunt operation. A pathological hallmark of PHH is extensive deposition of extracellular matrix (ECM) proteins in the subarachnoid space. Our previous study revealed that matrix metalloproteinase (MMP)-9, which degrades ECM proteins, may play an important role in the resolution of ventricular dilation. MMP-9 is known to be induced by hepatocyte growth factor (HGF) in various cell lines. AIMS: The aim of this study is to confirm our earlier finding that MMP-9 contributes to the resolution of PHH, and to investigate whether HGF also contributes to this process. STUDY DESIGN: Cerebrospinal fluid (CSF) samples were collected from 13 infants who developed ventricular dilation after intraventricular hemorrhage (IVH). Of these infants, 9 exhibited resolution of ventricular dilation without shunt operation; however, 4 infants had to be treated with shunt operation. The CSF levels of MMP-9 and HGF were measured using an enzyme immunoassay. RESULTS: Significantly higher CSF levels of MMP-9 and HGF were detected in patients in whom the ventricular dilation resolved without shunt operation than in those with progressive ventricular dilation (MMP-9: median, 128ng/ml; range, 47-900ng/ml vs median, 50ng/ml; range, 12-110ng/ml; p<0.05; HGF: median, 2.42ng/ml; range, 0.81-7.04ng/ml vs median, 1.42ng/ml; range, 0.67-3.87ng/ml; p<0.05). CONCLUSIONS: Our results indicate that MMP-9 and HGF may participate in the resolution of ventricular dilation following IVH.
Toshio Okamoto; Satoru Takahashi; Eiki Nakamura; Ken Nagaya; Tokitsugi Hayashi; Masaru Shirai; Kenji Fujieda
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Publication Detail:
Type:  Journal Article     Date:  2010-05-10
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  251-4     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Department of Pediatrics, Asahikawa Medical College, Hokkaido, Japan. <>
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MeSH Terms
Cerebral Ventricles / pathology
Hemorrhage / etiology*
Hepatocyte Growth Factor / cerebrospinal fluid*
Hydrocephalus / cerebrospinal fluid*,  complications
Immunoenzyme Techniques
Infant, Newborn
Infant, Newborn, Diseases / cerebrospinal fluid*
Matrix Metalloproteinase 9 / cerebrospinal fluid*
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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