Document Detail

Increased expression of keratinocyte interleukin-8 in human contact eczematous reactions to heavy metals.
MedLine Citation:
PMID:  8920803     Owner:  NLM     Status:  MEDLINE    
Heavy metal-induced contact eczematous human skin reactions to cobalt chloride and mercuric chloride were investigated for immunoreactivity to interleukin-8 (IL-8), by using an indirect immunoperoxidase staining technique. There was suprabasal epidermal staining for IL-8, with a decrease in the vicinity of areas with parakeratotic epithelium. However, in the immediate vicinity of a vesicular formation, intense staining of some apically situated keratinocytes was found. In addition, increased immunoreactivity over the acrosyringial area compared with the surrounding epidermis was obtained. These findings indicate an increased synthesis of keratinocyte IL-8 in contact eczematous skin.
L Chen; K Nordlind; S Lidén; M Sticherling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  509-14     Citation Subset:  IM    
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Dermatitis, Contact / physiopathology*
Eczema / physiopathology*
Interleukin-8 / metabolism*
Keratinocytes / metabolism*
Mercuric Chloride*
Skin Tests
Reg. No./Substance:
0/Interleukin-8; 7440-48-4/Cobalt; 7487-94-7/Mercuric Chloride; 7646-79-9/cobaltous chloride

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