Document Detail

Increased expression of epidermal growth factor receptors in the tracheal epithelia after topical mitomycin-C in rabbits.
MedLine Citation:
PMID:  15882829     Owner:  NLM     Status:  MEDLINE    
The aim is to examine histopathological changes and expression of epidermal growth factor receptor (EGFR) in tracheal epithelia caused by application of topical mitomycin-C (MMC) in rabbit model after the tracheotomy procedure. The conventional tracheotomy was performed in 16 rabbits. They were randomly divided into two equal groups. The first group was applied MMC at a concentration of 0.4 mg/ml around tracheotomy for 5 min, and the other group was not taken a treatment as a control. The animals were sacrificed at the end of 4 weeks. Their tracheas were evaluated with H&E and Masson's trichrome histochemically, and with antiepidermal growth factor receptor immunohistochemically. Results showed that there was no significant difference between MMC and control group for inflammatory cells (P=0.09). The numbers of fibroblasts and subepithelial tissue thickness in the group exposed to MMC were significantly lower than the control group (P<0.05). In contrast, the percentage of EGFR in the application of MMC group was significantly higher than the control group (P<0.05). The application of topical MMC on airway epithelia after tracheotomy showed significant elevation in the levels of epithelial EGFR expression compared to controls in a rabbit model. The activation of epithelial EGFR may facilitate epithelial healing, but further studies are needed to assess the effect of topical MMC on respiratory epithelia.
Hamdi Arbag; Mustafa Cihat Avunduk; Bedri Ozer; Kayhan Ozturk; Cagatay Han Ulku
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-26
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  32     ISSN:  0385-8146     ISO Abbreviation:  Auris Nasus Larynx     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-10     Completed Date:  2005-09-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Department of Otolaryngology, Head and Neck Surgery, University of Selcuk, Meram Medical School, Kulak Burun Bogaz Hastaliklari AD, Akyokus 42080, Konya, Turkey.
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MeSH Terms
Administration, Topical
Antibiotics, Antineoplastic / administration & dosage,  pharmacology*
Epithelium / drug effects,  metabolism
Mitomycin / administration & dosage,  pharmacology*
Postoperative Period
Random Allocation
Receptor, Epidermal Growth Factor / metabolism*
Trachea / cytology,  drug effects*,  metabolism*
Wound Healing / drug effects
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin; EC, Epidermal Growth Factor

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