Document Detail


Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate.
MedLine Citation:
PMID:  23054685     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammatory processes play an important role in the development of nasal polyps (NP), but the etiology and, to a high degree also, the pathogenesis of NP are not fully understood. The role of several cytokines and chemokines such as eotaxins, IL-4, IL-5, IL-6, IL-8, and RANTES has been reported in NP. Herewith, we investigated the expression and pattern of distribution of chemokine receptors CCR1 and CCR3 in nasal polyps. Immunohistochemical detection was carried out in frozen sections of biopsies from 22 NP and 18 nasal mucosa specimens in both the epithelial and stromal compartments. Fluorescence microscopy and computerized image analysis revealed a statistically significant increased number of CCR1 (45.2 ± 2.8 vs. 15.1 ± 1.9, p < 0.001)-positive as well as CCR3 (16.4 ± 1.4 vs. 9.7 ± 1.1, p < 0.001)-positive cells in the stroma of NP compared to nasal mucosa. In comparison to healthy nasal mucosa, increased positivity of CCR3 was detected in the epithelial compartment of NP. Our data suggest that increased expression of CCR1 and CCR3 chemokine receptors may, in accord with various chemokines, contribute to the pathogenesis of nasal polyposis by facilitating increased migration and prolonged accumulation of inflammatory cells, e.g., eosinophils, in the inflammatory infiltrate of NP.
Authors:
P Fundová; D P Funda; D Kovář; R Holý; M Navara; H Tlaskalová-Hogenová
Related Documents :
10706675 - Trail (apo2 ligand) and tweak (apo3 ligand) mediate cd4+ t cell killing of antigen-pres...
19672265 - The role of apoptotic cell death in the radiosensitising effect of gemcitabine.
15739095 - Molecular mechanisms of ginsenoside rh2-mediated g1 growth arrest and apoptosis in huma...
12516965 - 2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (xk469), an inhibitor of topois...
6227515 - Evidence of suppressor activity mediated by concanavalin-a stimulated cells towards asp...
21128005 - Apoptosis and autophagy in the regulation of t lymphocyte function.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Folia microbiologica     Volume:  -     ISSN:  1874-9356     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
ENT Department of the 3rd Faculty of Medicine, Charles University and the Central Military Hospital, U vojenské nemocnice 1200, 169 02, Prague 6, Czech Republic, pdfunda@seznam.cz.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An L-Type Calcium Channel Agonist, Bay K8644, Extends the Window of Intervention Against Ischemic Ne...
Next Document:  Effect of caffeine concentration on biomass production, caffeine degradation, and morphology of Aspe...