Document Detail

Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients.
MedLine Citation:
PMID:  17888430     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN: Molecular studies in human tissue. SETTING: A women's hospital in China. PATIENT(S): Fifty-five premenopausal women (25 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery or hysterectomy. INTERVENTION(S): Eutopic and ectopic endometrium tissue were obtained at the time of surgery. Peripheral sera were also collected on the same day. MAIN OUTCOME MEASURE(S): Immunohistochemical localization of c-fos in the endometrium, c-fos and MMP-9 protein levels in the endometrium, and 17beta-E(2) levels in the serum. RESULT(S): c-fos protein was predominantly located in the nuclei of glandular epithelial cells and stromal cells. c-fos and MMP-9 protein levels in paired eutopic and ectopic endometria from women with endometriosis were significantly higher than those in the endometrium from women without endometriosis. No significant difference in c-fos or MMP-9 protein levels was observed between paired eutopic and ectopic endometria. c-fos protein levels in endometrium positively correlated with endometrial MMP-9 levels and serum 17beta-E(2) levels. CONCLUSION(S): Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants.
Hong Pan; Jian-Zhong Sheng; Li Tang; Rong Zhu; Tian-Hua Zhou; He-Feng Huang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-20
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1000-7     Citation Subset:  IM    
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
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MeSH Terms
Endometriosis / metabolism*
Endometrium / metabolism*
Estradiol / metabolism*
Matrix Metalloproteinase 9 / metabolism*
Menstrual Cycle / metabolism
Middle Aged
Ovarian Diseases / metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 50-28-2/Estradiol; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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