Document Detail


Increased expression of biglycan mRNA in pressure-overloaded rat heart.
MedLine Citation:
PMID:  11728008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biglycan mRNA expression in rat myocardium after abdominal aortic banding with renal ischemia was examined. The Northern blot analysis demonstrated that expression of biglycan mRNA in the pressure-overloaded hearts on days 2, 7, 14 and 28 was 2.88 +/- 0.89, 2.32 +/- 0.49, 2.17 +/- 0.57 and 1.81 +/- 0.46-fold higher, respectively, than that in the sham-operated hearts. In situ hybridization showed an increased density of biglycan mRNA signal-positive cells in the pressure-overloaded hearts. The cells with positive signals were spindle-shaped mesenchymal cells in the myocardial interstitium. A marked increase in biglycan mRNA signal expression was also observed in endothelial cells and smooth muscle cells of the thickened myocardial capillary wall. These results demonstrated an increase in biglycan mRNA in the pressure-overloaded heart in mesenchymal cells in the myocardial interstitium, and in endothelial and smooth muscle cells of the capillaries, indicating that biglycan contributes to the ventricular and vascular remodeling in response to pressure overload.
Authors:
Y Ayada; S Kusachi; T Murakami; S Hirohata; S Takemoto; I Komatsubara; J Hayashi; A Iwabu; Y Ninomiya; T Tsuji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  23     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-30     Completed Date:  2002-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  633-43     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Northern
Capillaries / metabolism
Extracellular Matrix Proteins
Gene Expression
Hypertension / etiology,  genetics*,  physiopathology
In Situ Hybridization
Male
Myocardium / metabolism
Proteoglycans / genetics*
RNA, Messenger / genetics*,  metabolism*
Rats
Rats, Sprague-Dawley
Ventricular Remodeling / genetics,  physiology
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Proteoglycans; 0/RNA, Messenger; 123939-84-4/biglycan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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