Document Detail

Increased expression of VEGF following exercise training in patients with heart failure.
MedLine Citation:
PMID:  11298785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: During the last decades several angiogenic factors have been characterized but so far it is unknown whether local muscle exercise training increases the expression of these factors in patients with moderate heart failure. Expression of the major putative angiogenic factor vascular endothelial growth factor (VEGF) at the level of messenger RNA (mRNA) and/or protein was therefore studied before and after 8 weeks of training in patient with chronic heart failure. METHODS: VEGF mRNA and protein concentrations were determined in skeletal muscle biopsies before and after 8 weeks of one-legged knee extension training in patients with chronic heart failure (New York Heart Association II-III). RESULTS: Exercise training increased the citrate synthase activity and peripheral exercise capacity by 46% and 36%, respectively, in parallel with a two-fold increase in VEGF at both the mRNA (P = 0.03) and protein (P = 0.02) levels CONCLUSION: The increase in VEGF gene expression in response to exercise training indicates VEGF to be one possible mediator in exercise-induced angiogenesis and may therefore regulate an important and early step in adaptation to increased muscle activity in patient with chronic heart failure.
T Gustafsson; K Bodin; C Sylvén; A Gordon; R Tyni-Lenné; E Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  31     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-07-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Chronic Disease
Citrate (si)-Synthase / metabolism
Endothelial Growth Factors / biosynthesis*,  genetics
Heart Failure / enzymology,  metabolism*,  physiopathology*
L-Lactate Dehydrogenase / metabolism
Lymphokines / biosynthesis*,  genetics
Muscle Fibers, Skeletal / classification,  enzymology
Phosphofructokinase-1 / metabolism
RNA, Messenger / biosynthesis
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Work Capacity Evaluation
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/RNA, Messenger; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC Dehydrogenase; EC (si)-Synthase; EC

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