| Increased expression of TDP-43 in the skin of amyotrophic lateral sclerosis. | |
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MedLine Citation:
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PMID: 20175762 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: Transactivation-responsive DNA-binding protein-43 (TDP-43) was identified as a major component of the ubiquitin-positive inclusions in sporadic amyotrophic lateral sclerosis (ALS). However, there has been no study of TDP-43 in ALS skin. The present study investigates TDP-43 in ALS skin. MATERIALS AND METHODS: We made a quantitative immunohistochemical study of the expression of TDP-43 in the skin from 15 patients with ALS and 15 control subjects. RESULTS: The proportion of TDP-43-positive (TDP-43+) cells in the epidermis in ALS patients was significantly higher (P < 0.001) than in controls. There was a significant positive relationship (r = 0.62, P < 0.02) between the proportion and duration of illness in ALS patients. The optical density of TDP-43+ cells in the epidermis in ALS patients is markedly stronger (P < 0.001) than in controls. There was a significant positive relation (r = 0.72, P < 0.01) between the immunoreactivity and duration of illness in ALS patients. CONCLUSIONS: These data suggest that changes of TDP-43 in ALS skin are likely to be related to the disease process and that metabolic alterations of TDP-43 may take place in the skin of patients with ALS. |
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Authors:
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M Suzuki; H Mikami; T Watanabe; T Yamano; T Yamazaki; M Nomura; K Yasui; H Ishikawa; S Ono |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 122 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 367-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The Authors. Journal compilation © 2010 Blackwell Munksgaard. |
Affiliation:
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Department of Neurology, Teikyo University Chiba Medical Center, Ichihara, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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