| Increased expression of CD55 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. | |
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MedLine Citation:
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PMID: 22309963 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To analyze the expression of complement delay-accelerating factor (CD55) in nasopharyngeal carcinoma and its correlation with clinicopathologic features, including survival rate. Methods: Eighty-two nasopharyngeal carcinoma tissues were evaluated for CD55 expression using immunohistochemistry. The association between CD55 expression and various clinicopathological characteristics including overall survival was analyzed. Results: Immunohistochemical analysis revealed that the protein expression of CD55 detected in nasopharyngeal carcinoma tissues was higher than that in the normal nasopharyngeal tissue (P=0.003). In addition, high levels of CD55 protein were positively correlated with the status of lymph node metastasis (P=0.02) and distant metastasis (P=0.01), and clinical stage (P=0.002) of nasopharyngeal carcinoma patients. Patients with positive CD55 expression had a significantly shorter overall survival time than did patients with negative CD55 expression (P=0.001). Multivariate analysis suggested that the expression pattern of CD55 protein was an independent prognostic indicator (P=0.009) for the survival of patients with nasopharyngeal carcinoma. Conclusion: The data from this study suggest, for the first time, that CD55 is frequently expressed in nasopharyngeal carcinoma and its expression is associated with decreased patient survival; therefore, CD55 expression may be a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma. |
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Authors:
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Yumei Shen; Ruixue Yin; Xiaogang Deng; Hing Shen |
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Publication Detail:
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Type: Journal Article Date: 2012-02-01 |
Journal Detail:
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Title: Clinical and investigative medicine. Médecine clinique et experimentale Volume: 35 ISSN: 1488-2353 ISO Abbreviation: Clin Invest Med Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804071 Medline TA: Clin Invest Med Country: Canada |
Other Details:
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Languages: eng Pagination: E34 Citation Subset: IM |
Affiliation:
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. shenhongfimmu@163.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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