Document Detail


Increased expression of CD55 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
MedLine Citation:
PMID:  22309963     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: To analyze the expression of complement delay-accelerating factor (CD55) in nasopharyngeal carcinoma and its correlation with clinicopathologic features, including survival rate. Methods: Eighty-two nasopharyngeal carcinoma tissues were evaluated for CD55 expression using immunohistochemistry. The association between CD55 expression and various clinicopathological characteristics including overall survival was analyzed. Results: Immunohistochemical analysis revealed that the protein expression of CD55 detected in nasopharyngeal carcinoma tissues was higher than that in the normal nasopharyngeal tissue (P=0.003). In addition, high levels of CD55 protein were positively correlated with the status of lymph node metastasis (P=0.02) and distant metastasis (P=0.01), and clinical stage (P=0.002) of nasopharyngeal carcinoma patients. Patients with positive CD55 expression had a significantly shorter overall survival time than did patients with negative CD55 expression (P=0.001). Multivariate analysis suggested that the expression pattern of CD55 protein was an independent prognostic indicator (P=0.009) for the survival of patients with nasopharyngeal carcinoma. Conclusion: The data from this study suggest, for the first time, that CD55 is frequently expressed in nasopharyngeal carcinoma and its expression is associated with decreased patient survival; therefore, CD55 expression may be a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma.
Authors:
Yumei Shen; Ruixue Yin; Xiaogang Deng; Hing Shen
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Publication Detail:
Type:  Journal Article     Date:  2012-02-01
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  35     ISSN:  1488-2353     ISO Abbreviation:  Clin Invest Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E34     Citation Subset:  IM    
Affiliation:
. shenhongfimmu@163.com.
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