| Increased exposure of tissues to cortisol in late pregnancy. | |
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MedLine Citation:
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PMID: 5443967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In late normal pregnancy the mean day-night variation of non-protein-bound cortisol in plasma was found to be reduced to 52%, from a mean of 82% in non-pregnant subjects. Levels of unbound cortisol at midnight and at 9 a.m. in late pregnancy were raised above the non-pregnant normal. These levels led to increased urinary free cortisol excretion in pregnancy.This "tissue exposure" in late pregnancy is two to three times normal, as judged by both plasma unbound and urinary free cortisol measurements. The well-known increase in urinary free cortisol excretion in pregnancy is explained by the reduced day-night rhythm. |
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Authors:
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C W Burke; F Roulet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British medical journal Volume: 1 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1970 Mar |
Date Detail:
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Created Date: 1970-06-30 Completed Date: 1970-06-30 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 657-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gel Circadian Rhythm Cushing Syndrome / blood, urine Female Humans Hydrocortisone / blood*, urine Pregnancy* Protein Binding |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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