Document Detail


Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure.
MedLine Citation:
PMID:  9857108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide exerts multiple effects on renal function. It remains unclear whether endogenous nitric oxide production is increased or decreased in patients with chronic renal failure. To evaluate endogenous nitric oxide production in these patients we studied exhaled nitric oxide output by an ozone chemiluminescence method and plasma NO2(-)/NO3(-) levels by the Griess method in 40 patients with end-stage chronic renal failure who underwent regular continuous ambulatory peritoneal dialysis (n=30) or haemodialysis (n=10), and in 28 healthy subjects. Patients with chronic renal failure had a higher exhaled nitric oxide concentration [39+/-3 versus 19+/-1 parts per billion, (mean+/-S.E.M.), P<0.0001], a greater nitric oxide output (177+/-11 versus 96+/-7 nl.min-1.m-2, P<0.001) and a higher plasma NO2(-)/NO3(-) concentration (96+/-14 versus 33+/-4 micromol, P<0.01) than controls. These values did not differ between patients on haemodialysis and those on continuous ambulatory peritoneal dialysis. Patients with chronic renal failure had significantly higher plasma concentrations of both interleukin-1beta and interferon-gamma than controls. The exhaled nitric oxide output did not correlate with plasma NO2(-)/NO3(-) or with peritoneal dialysate NO2(-)/NO3(-), but plasma NO2(-)/NO3(-) correlated with dialysate NO2(-)/NO3(-) in patients who underwent continuous ambulatory peritoneal dialysis (r=0.77, P<0.01). Haemodialysis for 4 h acutely decreased plasma NO2(-)/NO3(-) (92+/-17 versus 50+/-8 micromol, P<0.05) and cGMP concentration (16.5+/-4.3 versus 5.1+/-1. 7 pmol/ml, P<0.01), but did not decrease exhaled nitric oxide output. The increase in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia.
Authors:
A Matsumoto; Y Hirata; M Kakoki; D Nagata; S i Momomura; T Sugimoto; H Tagawa; M Omata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  96     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Affiliation:
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Atrial Natriuretic Factor / blood
Breath Tests
Chemiluminescent Measurements
Chi-Square Distribution
Cyclic GMP / blood
Female
Humans
Interferon-gamma / blood
Interleukin-1 / blood
Kidney Failure, Chronic / metabolism*
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Nitrates / blood
Nitric Oxide / analysis,  blood,  metabolism*
Nitrites / blood
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis
Time Factors
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; 114471-18-0/Natriuretic Peptide, Brain; 7665-99-8/Cyclic GMP; 82115-62-6/Interferon-gamma; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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