Document Detail


Increased erythropoietin production in children with severe malarial anemia.
MedLine Citation:
PMID:  7485716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma immunoreactive erythropoietin concentrations were determined in 84 children with Plasmodium falciparum malaria in Gabon. There was an inverse log/linear relationship between hemoglobin or hematocrit and plasma erythropoietin, indicating that erythropoietin levels increased exponentially as circulating hemoglobin decreased. These result show that P. falciparum malaria does not lead to decreased erythropoietin production, and in turn reduced erythropoietin production does not contribute to the pathogenesis of malarial anemia. There is an adequate response of erythropoietin to anemia in children with P. falciparum malaria.
Authors:
G D Burchard; P Radloff; J Philipps; M Nkeyi; J Knobloch; P G Kremsner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  53     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  AIM; IM    
Affiliation:
Institute for Tropical Medicine, University of Tubingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Anemia / etiology,  metabolism*,  therapy
Blood Transfusion
Child
Child, Preschool
Erythropoietin / biosynthesis*
Female
Hematocrit
Hemoglobins / analysis
Humans
Infant
Malaria, Falciparum / complications*
Male
Parasitemia / complications*
Regression Analysis
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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