Document Detail

Increased erythropoietin production in children with severe malarial anemia.
MedLine Citation:
PMID:  7485716     Owner:  NLM     Status:  MEDLINE    
Plasma immunoreactive erythropoietin concentrations were determined in 84 children with Plasmodium falciparum malaria in Gabon. There was an inverse log/linear relationship between hemoglobin or hematocrit and plasma erythropoietin, indicating that erythropoietin levels increased exponentially as circulating hemoglobin decreased. These result show that P. falciparum malaria does not lead to decreased erythropoietin production, and in turn reduced erythropoietin production does not contribute to the pathogenesis of malarial anemia. There is an adequate response of erythropoietin to anemia in children with P. falciparum malaria.
G D Burchard; P Radloff; J Philipps; M Nkeyi; J Knobloch; P G Kremsner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  53     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  AIM; IM    
Institute for Tropical Medicine, University of Tubingen, Germany.
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MeSH Terms
Age Factors
Anemia / etiology,  metabolism*,  therapy
Blood Transfusion
Child, Preschool
Erythropoietin / biosynthesis*
Hemoglobins / analysis
Malaria, Falciparum / complications*
Parasitemia / complications*
Regression Analysis
Severity of Illness Index
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin

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