Document Detail

Increased erythropoietin production in anephric rats with hyperplasia of the reticuloendothelial system induced by colloidal carbon or zymosan.
MedLine Citation:
PMID:  1244926     Owner:  NLM     Status:  MEDLINE    
Adult rats were subjected sequentially to (1) administration of colloidal carbon, zymosan, or gadolinium; (2) subtotal hepatectomy, bilateral nephrectomy, or sham operation; and (3) a 6-hr bout of hypoxia, starting 1 hr or 24 hr after the operation. Control animals received the respective vehicles. The erythropoietin (Ep) activity was assayed in exhypoxic polycythemic mice on the basis of 48-hr per cent RBC(-59) Fe incorporation values. Ep levels in serum of anephric rats primed with either colloidal carbon or zymosan were considerably more elevated than in control animals. This potentiating effect was observed in rats subjected to hypoxia starting either 1 or 24 hr after nephrectomy. On the other hand, gadolinium did not enhance the extrarenal Ep response to hypoxia. It is emphasized that both colloidal carbon and zymosan induced marked hyperplasia of the hepatic and splenic reticuloendothelial system (RES), while gadolinium did not induce this effect. A strict correlation was thus established between potentiation of extrarenal Ep production and hyperplasia of the RES. It is therefore tentatively concluded that the RES is a source of extrarenal Ep. Additionally, since the liver plays a prominent role in extrarenal Ep production, Kupffer cells may represent a major source for Ep in the anephric rat. Finally, it is of interest that both colloidal carbon and zymosan did not potentiate the Ep response to hypoxia in sham-operated or subtotally hepatectomized rats.
C Peschle; G Marone; A Genovese; I A Rappaport; M Condorelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood     Volume:  47     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-37     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / etiology
Erythropoietin / biosynthesis*
Hyperplasia / chemically induced
Liver / anatomy & histology
Mononuclear Phagocyte System / pathology,  physiopathology*
Organ Size
Reg. No./Substance:
0/Colloids; 11096-26-7/Erythropoietin; 7440-44-0/Carbon; 7440-54-2/Gadolinium; 9010-72-4/Zymosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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