Document Detail

Increased erythrocyte sodium efflux during overfeeding without evidence of mediation by circulating catecholamines or thyroid hormone.
MedLine Citation:
PMID:  6387368     Owner:  NLM     Status:  MEDLINE    
Ten slightly obese middle-aged men were instructed to increase their energy intake 25% during a period of 1 week, which was preceded by a control period of seven days. Body weight increased by 0.67 kg (SD 0.60) indicating good compliance with the regimen. Transmembrane sodium fluxes were determined with the use of 22Na. The pre-diet erythrocyte sodium content was 9.7 mmol/L (SD 0.8) decreasing to 8.9 mmol/L (SD 1.1) (P less than 0.05) during overfeeding. The Na-efflux rate constant increased from 0.40 h-1 to 0.54 h-1 (P less than 0.05). Urinary excretion of catecholamines and concentrations of catecholamines and insulin in plasma and of thyroxine, triiodothyronine, and reverse T3 in serum did not change. Thus, overfeeding seems to enhance the total Na efflux in erythrocytes from slightly obese men. There were no measurable changes in thyroid hormone or catecholamine levels leaving the regulatory mechanisms unexplained.
B Fagerberg; H Herlitz; O Jonsson; J Nauclér; U Nilsson; T Hedner; G Lindstedt; O Andersson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  33     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-03     Completed Date:  1984-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  994-8     Citation Subset:  IM    
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MeSH Terms
Catecholamines / blood*,  physiology
Energy Intake*
Energy Metabolism*
Erythrocytes / metabolism*
Insulin / blood
Middle Aged
Obesity / blood*
Potassium / blood
Sodium / blood*
Thyroid Hormones / blood*,  physiology
Reg. No./Substance:
0/Catecholamines; 0/Thyroid Hormones; 11061-68-0/Insulin; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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