| Increased epicardial adipose tissue in type 1 diabetes is associated with central obesity and metabolic syndrome. | |
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MedLine Citation:
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PMID: 21035889 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS: the present study evaluated the relationship between metabolic syndrome (MS), body fat composition and epicardial adipose tissue (EAT) in type 1 diabetes. Epicardial adipose tissue is a new independent marker of coronary artery disease (CAD). METHODS: forty-five type 1 diabetic women were evaluated (age 36 ± 9 years; body mass index 24.6 ± 4.4 kg/m(2)). Metabolic syndrome was defined by the World Health Organization criteria. Body fat composition and EAT were analyzed by dual-energy-X-ray absorptiometry and echocardiogram, respectively. RESULTS: twenty patients (45%) had MS. Patients with MS had greater android (central) fat deposition than patients without MS (41.9 ± 2.0% vs. 33.7 ± 1.8%, p=0.004). Total body fat and gynoid (peripheric) fat distribution were similar between the groups. Mean EAT was higher in patients with MS (6.15 ± 0.34 mm vs. 4.96 ± 0.25 mm; p=0.006) and EAT was positively correlated with android (central) fat distribution (r=0.44; p=0.002), however no correlation was found with gynoid (peripheric) fat distribution. CONCLUSIONS: there was a high incidence of MS in type 1 diabetes related to increased central adiposity, despite the absence of obesity. Metabolic syndrome and central obesity were associated with increased EAT. Thus, young non-obese type 1 diabetic women with central adiposity and/or MS may have increased EAT, what may predict CAD risk. |
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Authors:
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Denise Prado Momesso; Isabela Bussade; Marcio Antonio Epifanio; Claudio Domenico Sahione Schettino; Luis Augusto Tavares Russo; Rosane Kupfer |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 91 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 47-53 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Diabetes, State Institute of Diabetes and Endocrinology, Catholic University of Rio de Janeiro, Rua Eduardo Guinle, 20/904, 22260-090 Rio de Janeiro, Brazil. dmomesso@terra.com.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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