Document Detail

Increased eosinophil cationic protein levels in bronchoalveolar lavage from wheezy infants.
MedLine Citation:
PMID:  11338288     Owner:  NLM     Status:  MEDLINE    
Although studies examining the serum suggest a role for eosinophils in wheezing episodes in infants and toddlers, the presence of a chronic eosinophilic inflammation within their airways remains to be demonstrated. In this study we investigated whether eosinophil cationic protein (ECP) levels are increased in BAL fluid (BALF) from infants and toddlers with recurrent wheezing episodes, during an asymptomatic period. The levels of ECP in BALF were quantitated by radioimmunoassay in 61 children (36 with severe recurrent episodes of wheezing and 25 who were non-wheezy), aged 6-36 months, in whom flexible bronchoscopy was clinically indicated. BALF eosinophil counts were < or = 1% in all patients and did not differ in wheezers, compared to non-wheezers. In contrast, ECP levels in BALF were > or = 2.2 micrograms/l in 18 of 36 (50%) wheezy infants but in only three of 25 (12%) control infants (p < 0.01). Neutrophil counts were significantly higher in the wheezer group than in the non-wheezer group (8.1 x 10(3) cells/ml vs. 3.0 x 10(3) cells/ml). ECP levels in the BALF were not correlated with the absolute number of eosinophils (r = 0.03; p = 0.8) but were correlated with the absolute number of neutrophils (r = 0.54; p = 0.001). There was no association between high ECP levels in BALF and the atopic status of the wheezers. In conclusion, ECP levels are increased in BALF from young children with recurrent wheezing episodes, even during relatively quiescent periods, suggesting a chronic increased cell activation in the lower airways.
I Azevedo; J de Blic; B B Vargaftig; M Bachelet; P Scheinmann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  12     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-09-13     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM U-285, Paris, France.
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MeSH Terms
Blood Proteins / analysis*
Bronchoalveolar Lavage Fluid / immunology*
Eosinophil Granule Proteins
Eosinophils / immunology*
Leukocyte Count
Respiratory Sounds / immunology*
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

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