Document Detail


Increased enkephalin in brain of rats prone to overconsuming a fat-rich diet.
MedLine Citation:
PMID:  20603139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have shown that the opioid enkephalin (ENK), acting in part through the hypothalamic paraventricular nucleus (PVN), can stimulate consumption of a high-fat diet. The objective of the present study was to examine sub-populations of Sprague-Dawley rats naturally prone to overconsuming a high-fat diet and determine whether endogenous ENK, in different brain regions, is altered in these animals and possibly contributes to their behavioral phenotype. An animal model, involving a measure of initial high-fat diet intake during a few days of access that predicts long-term intake, was designed to classify rats at normal weight that are either high-fat consumers (HFC), which ingest 35% more calories of the high-fat than low-fat chow diet, or controls, which consume similar calories of these two diets. Immediately after their initial access to the diet, the HFC compared to control rats exhibited significantly greater expression of ENK mRNA, in the PVN, nucleus accumbens and central nucleus of the amygdala, but not the arcuate nucleus or basolateral amygdala. This site-specific increase in ENK persisted even when the HFC rats were maintained on a chow diet, suggesting that it reflects an inherent characteristic that can be expressed independently of the diet. It was also accompanied by a greater responsiveness of the HFC rats to the stimulatory effect of a PVN-injected, ENK analogue, D-ala2-met-enkephalinamide, compared to saline on consumption of the high-fat diet. Thus, normal-weight rats predicted to overconsume a fat-rich diet exhibit disturbances in endogenous ENK expression and functioning that may contribute to their long-term, behavioral phenotype.
Authors:
G-Q Chang; O Karatayev; J R Barson; S-Y Chang; S F Leibowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-21
Journal Detail:
Title:  Physiology & behavior     Volume:  101     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2011-01-05     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / metabolism*
Animals
Brain Mapping*
Dietary Fats
Energy Intake / physiology
Enkephalins / genetics,  metabolism*
Food Preferences / physiology
Hyperphagia / metabolism*
Male
Neural Pathways / metabolism
Nucleus Accumbens / metabolism*
Paraventricular Hypothalamic Nucleus / metabolism*
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DA21518/DA/NIDA NIH HHS; R01 DA021518/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Enkephalins; 0/RNA, Messenger
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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