Document Detail

Increased endoneurial albumin in diabetic polyneuropathy.
MedLine Citation:
PMID:  4069375     Owner:  NLM     Status:  MEDLINE    
Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 +/- 12.6% SD, 3.8 times higher than control values (7.8 +/- 2.0% SD, n = 4). These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.
T Ohi; J F Poduslo; P J Dyck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  35     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-03     Completed Date:  1986-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1790-1     Citation Subset:  AIM; IM    
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MeSH Terms
Albumins / analysis*
Blood Physiological Phenomena
Capillary Permeability
Diabetic Neuropathies / blood,  metabolism*,  physiopathology
Spinal Nerves / analysis*
Sural Nerve / analysis*,  physiology
Grant Support
Reg. No./Substance:

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