| Increased dosage of carbidopa in parkinsonian patients on low carbidopa-levodopa regimen. Effect on levodopa bioavailability. | |
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MedLine Citation:
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PMID: 2713868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a 2.5-fold increase in daily carbidopa intake on the bioavailability of levodopa was studied in six patients with Parkinson's disease on a low chronic regimen of carbidopa-levodopa (Sinemet) at the fixed ratio of 1:10. The extent of levodopa absorption, expressed as the area under the 11-h plasma levodopa concentration-time curve (AUC0-11 h), was not enhanced by the higher carbidopa dose. A significant increase in the AUC was found for the levodopa metabolite 3-O-methyldopa at the higher carbidopa intake. Clinical performances of individual patients were identical with both carbidopa-levodopa ratios. From these data, an adequate inhibition of peripheral decarboxylation and hence a good bioavailability of levodopa may be expected in patients taking low doses of carbidopa-levodopa, using currently available commercial preparations. |
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Authors:
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M Contin; R Riva; P Martinelli; G Procaccianti; A Baruzzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 12 ISSN: 0362-5664 ISO Abbreviation: Clin Neuropharmacol Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-06-14 Completed Date: 1989-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM |
Affiliation:
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Institute of Neurology, University of Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Availability Carbidopa / administration & dosage*, therapeutic use Dose-Response Relationship, Drug Humans Levodopa / blood, pharmacokinetics*, therapeutic use Male Middle Aged Parkinson Disease / drug therapy* Tyrosine / analogs & derivatives, blood |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 38821-49-7/Carbidopa; 55520-40-6/Tyrosine; 7636-26-2/3-methoxytyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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