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Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.
MedLine Citation:
PMID:  21553300     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Olfactory dysfunction is a frequent and early feature of patients with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) and is very uncommon in patients with frontotemporal dementia (FTD). Mechanisms underlying this clinical manifestation are poorly understood but the premature deposition of protein aggregates in the olfactory bulb (OB) of these patients might impair its synaptic organization, thus accounting for the smell deficits. Tau, β-amyloid and alpha-synuclein deposits were studied in 41 human OBs with histological diagnosis of AD (n = 24), PD (n = 6), FTD (n = 11) and compared with the OB of 15 control subjects. Tau pathology was present in the OB of all patients, irrespective of the histological diagnosis, while β-amyloid and alpha-synuclein protein deposit were frequently observed in AD and PD, respectively. Using stereological techniques we found an increased number of dopaminergic periglomerular neurons in the OB of AD, PD and FTD patients when compared with age-matched controls. Moreover, volumetric measurements of OBs showed a significant decrease only in AD patients, while the OB volume was similar to control in PD or FTD cases. The increased dopaminergic tone created in the OBs of these patients could reflect a compensatory mechanism created by the early degeneration of other neurotransmitter systems and might contribute to the olfactory dysfunction exhibited by patients with neurodegenerative disorders.
Authors:
Iñaki-Carril Mundiñano; Maria-Cristina Caballero; Cristina Ordóñez; Maria Hernandez; Carla Dicaudo; Irene Marcilla; Maria-Elena Erro; Maria-Teresa Tuñon; Maria-Rosario Luquin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-8
Journal Detail:
Title:  Acta neuropathologica     Volume:  -     ISSN:  1432-0533     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Regenerative Therapy, Neuroscience Division, CIMA and Department of Neurology, Clínica Universidad de Navarra, Pamplona, Avenida de Pío XII 36, 31008, Pamplona, Spain.
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