| Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. | |
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MedLine Citation:
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PMID: 9398719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin is secreted in a pulsatile fashion. Rapid pulses are considered to be important for inhibiting hepatic glucose output, and ultradian pulses for stimulating peripheral glucose disposal. Aging is characterized by a progressive impairment in carbohydrate tolerance. We undertook the current studies to determine whether alterations in pulsatile insulin release accompany the age-related changes in carbohydrate metabolism. Healthy young (n = 8; body mass index, 21 +/- 1 kg/m2; age, 24 +/- 1 yr) and old (n = 9; body mass index, 24 +/- 1 kg/m2; age, 77 +/- 2 yr) volunteers underwent two studies. In the first study, insulin was sampled every 1 min for 150 min, and pulse analysis was conducted using a recently validated multiparameter deconvolution technique. In the second study, insulin was sampled every 10 min for 600 min, and insulin release was evaluated by Cluster analysis. In the 150-min studies, insulin secretory burst mass (P < 0.05) and amplitude (P < 0.01) were reduced in the elderly. In addition, approximate entropy, a measure of irregularity or disorderliness of insulin release, was increased in the aged (P < 0.01). In the 600-min studies, interpulse interval was greater in the aged (P < 0.05), and burst number was less (P < 0.05). We conclude that normal aging is characterized by more disorderly insulin release, a reduction in the amplitude and mass of rapid insulin pulses, and a decreased frequency of ultradian pulses. Whether these alterations in insulin pulsatility contribute directly to the age-related changes in carbohydrate metabolism will require further study. |
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Authors:
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G S Meneilly; A S Ryan; J D Veldhuis; D Elahi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 82 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-01-13 Completed Date: 1998-01-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4088-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of British Columbia, Vancouver, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activity Cycles
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physiology* Adult Aged Aging / metabolism* Blood Glucose / analysis Body Composition Body Constitution Cluster Analysis Female Glucose Clamp Technique Humans Insulin / blood, secretion* Male Osmolar Concentration |
| Grant Support | |
ID/Acronym/Agency:
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1K04-HD-00634/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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