Document Detail

Increased diameter of demyelinated axons in chronic multiple sclerosis of the spinal cord.
MedLine Citation:
PMID:  3226507     Owner:  NLM     Status:  MEDLINE    
In an autopsied case of chronic multiple sclerosis, many axons in some demyelinated plaques of the spinal cord had remarkably increased diameters and reduced argentophilia. The increase in axonal diameter extended for some distance and was restricted to the demyelinated areas. A review of 22 autopsy cases of chronic multiple sclerosis revealed similar findings in the plaques of the spinal cord in seven cases. They were also noted in the brain but much less frequently. On electron microscopy, the neurofilaments in these enlarged demyelinated axons were not closely packed but were separated by an increased amount of electron-lucent axoplasm. It is thought that this finding may be a manifestation of increased water content in the axoplasm secondary to increased permeability of the demyelinated axolemma.
M Shintaku; A Hirano; J F Llena
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  14     ISSN:  0305-1846     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:    1988 Nov-Dec
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Bronx, NY 10467.
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MeSH Terms
Multiple Sclerosis / pathology*
Nerve Fibers, Myelinated / pathology*
Spinal Cord / pathology*

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