Document Detail

Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus).
MedLine Citation:
PMID:  19393339     Owner:  NLM     Status:  MEDLINE    
Effect of dexamethasone (DEX, a synthetic glucocorticoid) on lipid metabolism in broiler chickens (Gallus gallus domesticus) was investigated. Male Arbor Acres chickens (1 wk old, n=30) were injected with DEX or saline for 1 wk, and a pair-fed group was included. DEX administration resulted in enhanced lipid deposition in adipose tissues. Plasma insulin increased about 3.3 fold in DEX injected chickens as against the control and hepatic triglyceride was higher as compared with the pair-fed chickens. In DEX injected chickens, the hepatic activities of malic enzyme (ME) and fatty acid synthetase (FAS) were significantly increased, while the mRNA levels of acetyl CoA carboxylase (ACC), ME, and FAS were significantly up-regulated, compared with the control. Although the mRNA levels of lipoprotein lipase (LPL), peroxisome proliferator-activated receptor-gamma (PPARgamma) and adipose triglyceride lipase (ATGL) genes in adipose tissue were not affected by DEX injection, ME activity and mRNA levels in abdominal fat pad of chickens treated with DEX are higher than those of control chickens. The results indicated that the increased hepatic de novo lipogenesis and in turn, the increased circulating lipid flux contributes to the augmented fat deposition in adipose tissues and liver in DEX-challenged chickens. The results suggest that glucocorticoids together with the induced hyperinsulinemia should be responsible for the up-regulated hepatic lipogenesis.
Yuanli Cai; Zhigang Song; Xinghao Zhang; Xiaojuan Wang; Hongchao Jiao; Hai Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-21
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  150     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Department of Animal Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
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MeSH Terms
Acetyl-CoA Carboxylase / genetics,  metabolism
Adipose Tissue / drug effects*,  enzymology,  metabolism
Chickens / metabolism*
Dexamethasone / administration & dosage,  pharmacology*
Fatty Acid Synthetase Complex / genetics,  metabolism
Gene Expression Regulation, Enzymologic / drug effects
Glucocorticoids / administration & dosage,  pharmacology*
Injections, Subcutaneous
Insulin / blood
Lipase / genetics,  metabolism
Lipogenesis / drug effects*
Lipoprotein Lipase / genetics,  metabolism
Liver / drug effects*,  enzymology,  metabolism
Malate Dehydrogenase / genetics,  metabolism
PPAR gamma / genetics,  metabolism
RNA, Messenger / metabolism
Triglycerides / metabolism
Uric Acid / blood
Weight Gain / drug effects
Reg. No./Substance:
0/Glucocorticoids; 0/PPAR gamma; 0/RNA, Messenger; 0/Triglycerides; 11061-68-0/Insulin; 50-02-2/Dexamethasone; 69-93-2/Uric Acid; EC Dehydrogenase; EC; EC Lipase; EC 6.-/Fatty Acid Synthetase Complex; EC Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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