Document Detail


Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus).
MedLine Citation:
PMID:  19393339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect of dexamethasone (DEX, a synthetic glucocorticoid) on lipid metabolism in broiler chickens (Gallus gallus domesticus) was investigated. Male Arbor Acres chickens (1 wk old, n=30) were injected with DEX or saline for 1 wk, and a pair-fed group was included. DEX administration resulted in enhanced lipid deposition in adipose tissues. Plasma insulin increased about 3.3 fold in DEX injected chickens as against the control and hepatic triglyceride was higher as compared with the pair-fed chickens. In DEX injected chickens, the hepatic activities of malic enzyme (ME) and fatty acid synthetase (FAS) were significantly increased, while the mRNA levels of acetyl CoA carboxylase (ACC), ME, and FAS were significantly up-regulated, compared with the control. Although the mRNA levels of lipoprotein lipase (LPL), peroxisome proliferator-activated receptor-gamma (PPARgamma) and adipose triglyceride lipase (ATGL) genes in adipose tissue were not affected by DEX injection, ME activity and mRNA levels in abdominal fat pad of chickens treated with DEX are higher than those of control chickens. The results indicated that the increased hepatic de novo lipogenesis and in turn, the increased circulating lipid flux contributes to the augmented fat deposition in adipose tissues and liver in DEX-challenged chickens. The results suggest that glucocorticoids together with the induced hyperinsulinemia should be responsible for the up-regulated hepatic lipogenesis.
Authors:
Yuanli Cai; Zhigang Song; Xinghao Zhang; Xiaojuan Wang; Hongchao Jiao; Hai Lin
Related Documents :
7877939 - Effects of dietary thiouracil on thyroid activity, egg production, and eggshell quality...
3588499 - Alterations in carotenoid metabolism during ochratoxicosis in young broiler chickens.
19762869 - Pediocin a improves growth performance of broilers challenged with clostridium perfring...
16359119 - Effects of dietary coenzyme q10 supplementation on hepatic mitochondrial function and t...
19904639 - Previous exposure to dietary phytase reduces the endogenous energy losses from precisio...
15510549 - Impact of dietary supplemental methionine sources on sensory measurement of odor-relate...
10450299 - The effects of dietary patterns on quality of life: a substudy of the dietary approache...
23031559 - Meta-analysis of the response of growing pigs to the isoleucine concentration in the diet.
1652199 - Calcium, magnesium, zinc, and iron balances in young women: effects of a low-phytate ba...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-21
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  150     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetyl-CoA Carboxylase / genetics,  metabolism
Adipose Tissue / drug effects*,  enzymology,  metabolism
Animals
Chickens / metabolism*
Dexamethasone / administration & dosage,  pharmacology*
Fatty Acid Synthetase Complex / genetics,  metabolism
Gene Expression Regulation, Enzymologic / drug effects
Glucocorticoids / administration & dosage,  pharmacology*
Injections, Subcutaneous
Insulin / blood
Lipase / genetics,  metabolism
Lipogenesis / drug effects*
Lipoprotein Lipase / genetics,  metabolism
Liver / drug effects*,  enzymology,  metabolism
Malate Dehydrogenase / genetics,  metabolism
Male
PPAR gamma / genetics,  metabolism
RNA, Messenger / metabolism
Triglycerides / metabolism
Uric Acid / blood
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/PPAR gamma; 0/RNA, Messenger; 0/Triglycerides; 11061-68-0/Insulin; 50-02-2/Dexamethasone; 69-93-2/Uric Acid; EC 1.1.1.37/Malate Dehydrogenase; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase; EC 6.-/Fatty Acid Synthetase Complex; EC 6.4.1.2/Acetyl-CoA Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells.
Next Document:  Using UMLS to construct a generalized hierarchical concept-based dictionary of brain functions for i...