Document Detail

Increased daytime somnolence despite normal sleep patterns in patients treated for nonfunctioning pituitary macroadenoma.
MedLine Citation:
PMID:  17666479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In patients treated for nonfunctioning pituitary macroadenoma (NFMA), increased fatigue scores on quality of life (QoL) have been reported. Because this may be related to altered sleep patterns, we evaluated daytime sleepiness and sleep patterns in patients successfully treated for NFMA in our center.
DESIGN: This is a case-control study.
PATIENTS AND METHODS: We assessed sleepiness and sleep patterns in 76 adult patients (41 men, mean age 63 yr, range 37-87) in remission of NFMA during long-term follow-up (10 yr, range 0.5-30) after surgical (n = 76) and additional radiotherapeutical (n = 28) treatment. We used two validated questionnaires for sleep parameters (Epworth Sleepiness Scale and Münchener Chronotype Questionnaire) and four validated questionnaires for QoL (Hospital Anxiety and Depression Scale, Multidimensional Fatigue Inventory-20, Nottingham Health Profile, and Short Form-36). Patient outcomes were compared with 76 healthy controls.
RESULTS: Sleep duration and timing of sleep were not affected compared with healthy controls. However, sleepiness score was increased in patients compared with controls (7.6 +/- 4.6 vs. 4.8 +/- 3.1; P < 0.001), reflecting increased daytime sleepiness in patients. There were no correlations between any of the sleep pattern parameters (duration, onset, rise time, or midsleep) and sleepiness scores. Sleepiness scores were significantly correlated to 15 of the 21 QoL parameters, whereas sleep patterns were not. Sleep timing was influenced by previous radiotherapy, whereas sleep duration was negatively affected by panhypopituitarism.
CONCLUSION: Daytime sleepiness is increased despite normal sleep patterns in patients treated for NFMA.
Agatha A van der Klaauw; Olaf M Dekkers; Alberto M Pereira; Klaas W van Kralingen; Johannes A Romijn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-31
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  92     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-21     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3898-903     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / epidemiology*,  radiotherapy*
Aged, 80 and over
Case-Control Studies
Disorders of Excessive Somnolence / epidemiology*
Fatigue / etiology
Follow-Up Studies
Health Status
Hypopituitarism / epidemiology
Linear Models
Middle Aged
Pituitary Neoplasms / epidemiology*,  radiotherapy*
Quality of Life
Remission Induction
Visual Fields

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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