Document Detail


Increased cytochrome c correlates with poor survival in aggressive lymphoma.
MedLine Citation:
PMID:  20798784     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma. This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance.
Authors:
Sarah T Wilkinson; David B F Johnson; Heather L Tardif; Margaret E Tome; Margaret M Briehl
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Oncology letters     Volume:  1     ISSN:  1792-1082     ISO Abbreviation:  -     Publication Date:  2010 3 
Date Detail:
Created Date:  2010-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  227-230     Citation Subset:  -    
Affiliation:
Department of Pathology, University of Arizona, Tucson, AZ 85724.
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Grant Support
ID/Acronym/Agency:
R01 CA071768-12S1//NCI NIH HHS; R01 CA071768-13//NCI NIH HHS; T32 CA009213-29//NCI NIH HHS

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