Document Detail

Increased cx43 and angiogenesis in exercised mouse hearts.
MedLine Citation:
PMID:  17455119     Owner:  NLM     Status:  MEDLINE    
Several studies focused on the macroscopic architecture of increased cardiac wall induced by exercise training. Our goal was to evaluate myocardiocyte, interstitial and vascular component, and connexin-43 expression in endurance-trained mouse hearts. Sixty-three 10-week-old male Swiss mice were divided into four sedentary groups (C0, C15, C30 and C45) and three groups exercised respectively for 15 (T15-D; running intensity [RI]: 3.18 m/min; running duration [RD]: 75 min/first week and 150 min/second week), 30 (T30-D; RI: 3.96 m/min; RD: 150 min/third week and 225 min/fourth week) and 45 days (T45-D; RI: 3.96 m/min and 4.8 m/min, respectively for the fifth and sixth week; RD: 300 min) on a treadmill. Morphometric analyses were performed to quantify myocardiocyte size and number, and the capillary and interstitial connective tissue (ICT) area. We assessed the expression of ventricle myosin light chain-II, vimentin and connexin-43 by western blot analyses. Our results showed a hypertrophy of the interventricular septum and left ventricle in T30-D and T45-D mice that was not due to variations in myofibrillar content, myocardiocyte size and number, or ICT quantity but to a significant increase in the capillary area. The microvascular remodeling was associated with vimentin increased expression in ICT cells and connexin-43 upregulation. The first phenomenon might be related to an enhanced request of remodeling and growth factors; the second suggests a new role of connexin-43 in cardiac angiogenesis.
M Bellafiore; G Sivverini; D Palumbo; F Macaluso; A Bianco; A Palma; F Farina
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Publication Detail:
Type:  Journal Article     Date:  2007-04-23
Journal Detail:
Title:  International journal of sports medicine     Volume:  28     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-28     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
Department of Experimental Medicine, University of Palermo, Palermo, Italy.
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MeSH Terms
Cardiomegaly / physiopathology*
Connective Tissue / physiopathology*
Connexin 43 / biosynthesis*
Gap Junctions
Neovascularization, Physiologic / physiology*
Physical Endurance / physiology*
Reg. No./Substance:
0/Connexin 43

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