| Increased cx43 and angiogenesis in exercised mouse hearts. | |
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MedLine Citation:
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PMID: 17455119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies focused on the macroscopic architecture of increased cardiac wall induced by exercise training. Our goal was to evaluate myocardiocyte, interstitial and vascular component, and connexin-43 expression in endurance-trained mouse hearts. Sixty-three 10-week-old male Swiss mice were divided into four sedentary groups (C0, C15, C30 and C45) and three groups exercised respectively for 15 (T15-D; running intensity [RI]: 3.18 m/min; running duration [RD]: 75 min/first week and 150 min/second week), 30 (T30-D; RI: 3.96 m/min; RD: 150 min/third week and 225 min/fourth week) and 45 days (T45-D; RI: 3.96 m/min and 4.8 m/min, respectively for the fifth and sixth week; RD: 300 min) on a treadmill. Morphometric analyses were performed to quantify myocardiocyte size and number, and the capillary and interstitial connective tissue (ICT) area. We assessed the expression of ventricle myosin light chain-II, vimentin and connexin-43 by western blot analyses. Our results showed a hypertrophy of the interventricular septum and left ventricle in T30-D and T45-D mice that was not due to variations in myofibrillar content, myocardiocyte size and number, or ICT quantity but to a significant increase in the capillary area. The microvascular remodeling was associated with vimentin increased expression in ICT cells and connexin-43 upregulation. The first phenomenon might be related to an enhanced request of remodeling and growth factors; the second suggests a new role of connexin-43 in cardiac angiogenesis. |
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Authors:
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M Bellafiore; G Sivverini; D Palumbo; F Macaluso; A Bianco; A Palma; F Farina |
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Publication Detail:
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Type: Journal Article Date: 2007-04-23 |
Journal Detail:
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Title: International journal of sports medicine Volume: 28 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-28 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 749-55 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, University of Palermo, Palermo, Italy. bellafiore@unipa.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomegaly / physiopathology* Connective Tissue / physiopathology* Connexin 43 / biosynthesis* Gap Junctions Male Mice Neovascularization, Physiologic / physiology* Physical Endurance / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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