Document Detail


Increased cortical excitability after selective REM sleep deprivation in healthy humans: a transcranial magnetic stimulation study.
MedLine Citation:
PMID:  23343775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: REM sleep has antiepileptogenic properties whereas, its loss is known to have a proconvulsive role. However, the mechanisms underlying the proepileptogenic effects of REM sleep deprivation are yet not fully understood. The aim of our study was to evaluate the effects of selective REM sleep deprivation (SRD) on cortical excitability in healthy subjects by means of transcranial magnetic stimulation (TMS).
METHODS: Ten normal subjects underwent three TMS sessions: (1) in baseline condition (BL), (2) after SRD by awakening them at each REM sleep onset and (3) after non-rapid eye movement sleep awakenings (NREM-A) as control for potential non-specific effects of interruptions. The TMS investigation included two protocols: (a) the evaluation of motor evoked potentials (MEPs) and silent period (SP) parameters, recorded in response to single pulse magnetic stimulation; (b) the evaluation of the time course of intracortical motor activity tested with paired-pulse TMS applied at inter-stimulus intervals of 1-10 ms.
RESULTS: After SRD the principal finding observed using single pulse TMS was a significant reduction in the duration of SP whereas, a reduction of intracortical inhibition was found, using the paired-pulse TMS. TMS parameters did not show significant changes after NREM-A with respect to BL.
CONCLUSIONS: SRD may influence cortical excitability with a reduction of inhibitory intracortical mechanisms, thus supporting the proconvulsant role of REM loss.
Authors:
Fabio Placidi; Silvana Zannino; Maria Albanese; Andrea Romigi; Francesca Izzi; Maria G Marciani; Maria G Palmieri
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Publication Detail:
Type:  Journal Article     Date:  2013-01-21
Journal Detail:
Title:  Sleep medicine     Volume:  14     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-20     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  288-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neurosciences, University of Rome Tor Vergata, Roma, Italy. fbplacidi@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Cortex / physiology*
Evoked Potentials, Motor / physiology*
Female
Humans
Male
Neural Inhibition / physiology
Reference Values
Sleep Deprivation / physiopathology*
Sleep, REM / physiology*
Transcranial Magnetic Stimulation*
Young Adult
Comments/Corrections
Comment In:
Sleep Med. 2013 Jul;14(7):585-6   [PMID:  23751183 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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