| Increased coronary artery blood flow with aortomyoplasty in chronic heart failure. | |
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MedLine Citation:
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PMID: 11216762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We hypothesized that diastolic counter-pulsation using aortomyoplasty will increase coronary blood flow. METHODS: In dogs (n = 6, 20 to 25 kg), the left latissimus dorsi muscle was isolated, wrapped around the descending thoracic aorta, and conditioned by chronic electrical stimulation. Heart failure was induced by rapid ventricular pacing. In a terminal study, left ventricular and aortic pressures, and blood flow in the left anterior descending coronary artery and descending aorta were measured. The endocardial-viability ratio was calculated. RESULTS: Aortomyoplasty increased mean diastolic aortic pressure (70 +/- 5 to 75 +/- 5 mm Hg, p < 0.05) and reduced peak left ventricular pressure (86 +/- 4 to 84 +/- 4 mm Hg, p < 0.05), leading to a 16% increase in endocardial-viability ratio (1.29 +/- 0.05 to 1.49 +/- 0.05, p < 0.05). Coronary blood flow was increased by 15% (8.2 +/- 1.5 to 9.4 +/- 1.6 mL/min, p < 0.05). During muscle contraction, 2.7 +/- 0.5 mL was ejected from the wrapped aortic segment. CONCLUSIONS: These data demonstrate that aortomyoplasty provides successful diastolic counterpulsation after muscle conditioning and heart failure. |
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Authors:
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B L Cmolik; D R Thompson; J T Sherwood; A S Geha; D T George |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 71 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-16 Completed Date: 2001-03-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiothoracic Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5011, USA. blc3@po.cwru.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyoplasty* Counterpulsation / methods* Dogs Heart Failure / physiopathology, surgery* Hemodynamics Ventricular Function, Left Ventricular Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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