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Increased conjunctival expression of protease activated receptor 2 (PAR-2) in seasonal allergic conjunctivitis: a role for abnormal conjunctival epithelial permeability in disease pathogenesis?
MedLine Citation:
PMID:  21558289     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims Aeroallergen exposure to the conjunctival epithelium in seasonal allergic conjunctivitis (SAC) may induce a cellular stress response that disrupts the barrier properties of the conjunctival epithelium, resulting in allergic disease. Whether such changes occur in SAC is unknown. Epithelial permeability is known to be increased when protease activated receptor 2 (PAR-2) is activated. We evaluated the expression of PAR-2 in patients with SAC-in-season (SACS) and compared it with control non-atopic subjects or those with out-of-season allergic conjunctivitis (OSAC). Methods Six SACS, eight normal and four OSAC specimens were examined immunohistochemically for PAR-2 and quantified in a masked fashion for the percentage of epithelia stained for each marker using Image-J software. Conjunctival epithelial heights were measured in all groups to confirm the presence of allergic eye disease. Results Mean percentage staining of PAR-2 was significantly greater in SACS that in normal specimens (73.4±15.4% vs 32.8±30.0%, p=0.038) or in OSAC (73.4±15.4% vs 1.4±2.2%, p=0.01). Mean conjunctival epithelial height was significantly raised in SACS (63.8±9.0 μm) versus controls (44.7±11.2 μm) (p=0.003, unpaired t test). Conclusions Conjunctival epithelial PAR-2 is significantly upregulated in SAC. This supports the view that disruption of the barrier properties of the conjunctival epithelium is an important event in SAC pathogenesis.
Authors:
S Yeoh; M Church; P Lackie; J McGill; M Mota; P Hossain
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-10
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  -     ISSN:  1468-2079     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Inflammation & Immunity, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
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