Document Detail

Increased concentrations of neopterin in plasma, ascites and ovarian cyst fluid in malignant tumours compared with benign ovarian tumours.
MedLine Citation:
PMID:  8967734     Owner:  NLM     Status:  MEDLINE    
Neopterin is a marker of the activation of cell-mediated immunity. The aim was to determine whether the concentrations of neopterin differ in plasma, ascites and ovarian cyst fluid between patients with ovarian cancer and patients with benign ovarian tumours. Neopterin was measured in 29 patients with cystic ovarian tumours of unknown histology. 14 ovarian cancers and 15 benign ovarian tumours were diagnosed histologically. Patient age and tumour size did not differ significantly between the groups. Neopterin levels were determined in plasma, and in ascites and cyst fluid by ELISA. The neopterin concentration in plasma, ascites and ovarian cyst fluid was significantly higher in patients with ovarian cancer compared with patients with benign ovarian tumours of the same size. The study shows that activation of cell-mediated immunity, defined as increased formation of neopterin, was increased in patients with ovarian cancer compared with patients with benign ovarian tumours.
M Haeger; M Swahn; M Hahlin; G Horvath; A Bengtsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  16     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  3189-92     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Ascites / metabolism*
Middle Aged
Neoplasm Proteins / metabolism*
Ovarian Cysts / metabolism*
Ovarian Neoplasms / blood,  metabolism*
Reg. No./Substance:
0/Neoplasm Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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